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ChemicalBook--->CAS DataBase List--->67287-39-2

67287-39-2

67287-39-2 Structure

67287-39-2 Structure
IdentificationBack Directory
[Name]

R(+)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE
[CAS]

67287-39-2
[Synonyms]

SKF 81297C
SKF-81297 HBr
R(+)-SKF-81297 HYDROBROMIDE
9-chloro-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol:hydrobromide
(R)-6-Chloro-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol hydrobromide
R(+)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE
[Molecular Formula]

C16H17BrClNO2
[MDL Number]

MFCD00671792
[MOL File]

67287-39-2.mol
[Molecular Weight]

370.67
Chemical PropertiesBack Directory
[Melting point ]

>256°C (dec.)
[storage temp. ]

Hygroscopic, -20°C Freezer, Under inert atmosphere
[solubility ]

H2O: 6 mg/mL
[form ]

solid
[color ]

white to off-white
Safety DataBack Directory
[WGK Germany ]

3
Hazard InformationBack Directory
[Hazard]

A poison.
[Uses]

SKF 81297C is a dopamine D1 agonist (1).
[Biological Activity]

skf 81297 hydrobromide is a selective agonist of the dopamine d1-like receptor, with a ki value of 1.9 nm. the dopamine d1-like receptors, consisting of d1 and d5 subtypes, are a subfamily of dopamine receptors that mediate excitatory neurotransmission after binding the endogenous neurotransmitter dopamine. the dopamine d1-like receptors have been implicated in dopaminergic regulation of a variety of fundamental neurophysiologic processes including mood, motivation, cognitive function, as well as motor activity.1. neumeyer jl, kula ns, bergman j, baldessarini rj. receptor affinities of dopamine d1 receptor-selective novel phenylbenzazepines. european journal of pharmacology, 2003, 474(2-3): 137-140.2. undieh as. pharmacology of signaling induced by dopamine d(1)-like receptor activation. pharmacology & therapeutics, 2010, 128(1): 37-60.3. vermeulen rj, drukarch b, sahadat mc, et al. the dopamine d1 agonist skf 81297 and the dopamine d2 agonist ly 171555 act synergistically to stimulate motor behavior of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned parkinsonian rhesus monkeys. movement disorders, 1994, 9(6): 664-672.
[in vivo]

SKF 81297 hydrobromide (0.05-0.3 mg/kg, i.m., once) stimulates motor behaviour of MPTP-lesioned monkeys[1].

Animal Model:Four male rhesus monkeys (Macaca mulatta, 7.0-11.3 kg)[1]
Dosage:0.05-0.3 mg/kg
Administration:Injected intramuscularly (i.m.), once
Result:Significantly increased rotational behaviour and right-sided hand use in unilateral MPTP-lesioned rhesus monkeys.
[IC 50]

D1 Receptor
[storage]

+4°C (desiccate)
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