| Identification | Back Directory | [Name]
CP-863187 | [CAS]
668981-02-0 | [Synonyms]
CP-863187
CP-281384
CP 281384,CP281384
CP-863187 >=98% (HPLC)
1,2,4-Triazolo[4,3-a]pyridine, 6-[4-(2,5-difluorophenyl)-5-oxazolyl]-3-(1-methylethyl)- | [Molecular Formula]
C18H14F2N4O | [MDL Number]
MFCD30480740 | [MOL File]
668981-02-0.mol | [Molecular Weight]
340.33 |
| Chemical Properties | Back Directory | [density ]
1.39±0.1 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
DMSO: 10mg/mL, clear | [form ]
powder | [pka]
2.42±0.50(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Biological Activity]
CP-863187 is a potent p38α (p38α) inhibitor (IC50 = 5.8 nM) with 44-fold selectivity over p38β (p38β) and no inhibitory potency against p38γ (p38γ) and p38δ (p38δ) isoforms. CP-863187 effectively inhibits LPS-stimulated cellular TNF-α production in vitro (IC50 = 259 and 25 nMusing human whole blood and isolated mononuclear cellsrespectively) and in rats in vivo (ED50 = 0.3 mg/kg p.o.) with good pharmacokinetic profile and oral availability (F = 87%/dog40%/monkey30%/r at with 5 mg/kg oral dosage; F = 66%/r at with 50 mg/kg oral dosage). |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|