| Identification | Back Directory | [Name]
PYRIDINE-2-SULFONYL CHLORIDE | [CAS]
66715-65-9 | [Synonyms]
TAK439 Impurity
PYRIDINE-2-SULFONYL
Vonoprazan Impurity 38
2-Pyridylsulfonyl chloride
Pyridin-2-sulfonyl chloride
2-Pyridinesulfonyl chloride
PYRIDINE-2-SULFONYL CHLORIDE
2-Pyridinylsulfonyl chloride
Pyridine-2-sulphonyl chloride
2-Pyridinesulfonyl Chloride, Technical Grade
PYRIDINE-2-SULFONYL CHLORIDE ISO 9001：2015 REACH | [Molecular Formula]
C5H4ClNO2S | [MDL Number]
MFCD01632222 | [MOL File]
66715-65-9.mol | [Molecular Weight]
177.61 |
| Chemical Properties | Back Directory | [Boiling point ]
284℃ | [density ]
1.488 | [Fp ]
126℃ | [solubility ]
Acetonitrile (Slightly), Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) | [form ]
Oil to Low-Melting Solid | [pka]
-5.12±0.19(Predicted) | [color ]
Colourless to Pale Yellow | [Stability:]
Hygroscopic, Moisture sensitive, Temperature sensitive |
| Hazard Information | Back Directory | [Uses]
2-Pyridinesulfonyl Chloride is used for preparation of pyridinesulfonyl derivatives. | [Preparation]
Pyridine-2-sulfonyl Chloride is generated as needed from 2,2′-Dipyridyl Disulfide. Treatment of 2,2′- dipyridyl disulfide in petroleum ether or dichloromethane with either Chlorine or Bromine at 20 °C results in 2- pyridinesulfenyl halide generation after 1-2 h. Isolation through evaporation of solvent provides a yellow powder with a pungent odor.
| [Precautions]
Pyridine-2-sulfonyl Chloride demonstrates instability, especially in the presence of moisture. Although the isolated powder may tolerate short-term storage in a well sealed vial or ampule, most work involving these reagents has utilized freshly prepared material.
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