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ChemicalBook--->CAS DataBase List--->66635-93-6

66635-93-6

66635-93-6 Structure

66635-93-6 Structure
IdentificationBack Directory
[Name]

(R)-(+)-Ketorolac
[CAS]

66635-93-6
[Synonyms]

(R)-Ketorolac
(R)-(+)-Ketorolac
Ketorolac R-IsoMer
(R)-(+)-Ketorolac ISO 9001:2015 REACH
Ketorolac impurity 1/Ketorolac R-Isomer
(1R)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
1H-Pyrrolizine-1-carboxylic acid, 5-benzoyl-2,3-dihydro-, (1R)-
[Molecular Formula]

C15H13NO3
[MDL Number]

MFCD00871492
[MOL File]

66635-93-6.mol
[Molecular Weight]

255.27
Chemical PropertiesBack Directory
[Melting point ]

163-170°C
[storage temp. ]

-20°C
[solubility ]

Chloroform (Slightly), Methanol (Slightly)
[form ]

powder
[color ]

white to beige
[optical activity]

[α]/D +162 to +178°, c = 1 in methanol
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319-H335
[Precautionary statements ]

P305+P351+P338
Hazard InformationBack Directory
[Chemical Properties]

Off-White Solid
[Uses]

(R)-Ketorolac is the R-enantiomer of Ketorolac. The (S)-enantiomer is about 60 times more potent than (R)-enantiomer. Prostaglandin biosynthesis inhibitor. Analgesic; anti-inflammatory.
[Definition]

ChEBI: A 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid that has R configuration. Unlike the S-enantiomer, it does not exhibit COX1 and COX2 inhibition, but does exhibit analgesic activity. Racemic keto olac, known simply as ketorolac, is used (mainly as a tromethamine salt) as a potent analgesic for the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis.
[Biochem/physiol Actions]

R-Ketorolac is potent and selective Rho-family GTPases Cdc42 (cell division control protein 42) and Rac1 (Ras-related C3 botulinum toxin substrate 1) allosteric inhibitor that modulates downstream GTPase-dependent physiologic responses critical to tumor metastasis. R-ketorolac significantly inhibits ovarian cancer cell adhesion, migration, and invasion.
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