| Identification | Back Directory | [Name]
1-Oleoyl Lysophosphatidic Acid | [CAS]
65528-98-5 | [Synonyms]
WRGQSWVCFNIUNZ-GDCKJWNLSA-N
1-Oleoyl Lysophosphatidic Acid Exclusive
9-Octadecenoic acid (9Z)-, (2R)-2-hydroxy-3-(phosphonooxy)propyl ester | [Molecular Formula]
C21H41O7P | [MDL Number]
MFCD12912350 | [MOL File]
65528-98-5.mol | [Molecular Weight]
436.52 |
| Chemical Properties | Back Directory | [Boiling point ]
581.5±60.0 °C(Predicted) | [density ]
1.103±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 2 mg/ml; DMSO: 2.5 mg/ml; Ethanol: 25 mg/ml; PBS (pH 7.2): 3 mg/ml | [form ]
Liquid | [pka]
1.82±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate) is an abundant lysophosphatidic acid (LPA) species with high biological activity due to its strong affinity for the LPA receptors. 1-Oleoyl lysophosphatidic acid is commonly used in most laboratories as a reagent for LPA receptor activation[1]. 1-Oleoyl lysophosphatidic acid increases SRE-driven β-galactosidase activity[2]. | [Definition]
ChEBI: 1-oleoyl-sn-glycerol 3-phosphate is a 1-acyl-sn-glycerol 3-phosphate having oleoyl as the 1-O-acyl group. It is a conjugate acid of a 1-oleoyl-sn-glycero-3-phosphate(2-). | [in vivo]
1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate) (0.4-2 μg; i.c.v.; 9-week-old male Wistar rats) induces anxiety-like responses in the elevated plus maze (EPM) under novelty conditions[1]. | Animal Model: | 9-week-old male Wistar rats[1] | | Dosage: | 0.4-2 μg | | Administration: | I.c.v. | | Result: | Reduced open arm exploration under novelty conditions and had no effect under habituated conditions in the EPM.
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| [References]
[1] Castilla-Ortega E, et al. 1-Oleoyl lysophosphatidic acid: a new mediator of emotional behavior in rats. PLoS One. 2014;9(1):e85348. Published 2014 Jan 7. DOI:10.1371/journal.pone.0085348
[2] Perkins LM, et al. Activation of serum response element-regulated genes by lysophosphatidic acid. Nucleic Acids Res. 1994;22(3):450-452. DOI:10.1093/nar/22.3.450 |
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