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ChemicalBook--->CAS DataBase List--->648926-15-2

648926-15-2

648926-15-2 Structure

648926-15-2 Structure
IdentificationBack Directory
[Name]

Glycogen Phosphorylase Inhibitor
[CAS]

648926-15-2
[Synonyms]

Glycogen Phosphorylase Inhibitor
2-chloro-4,5-difluoro-N-[[2-methoxy-5-(methylcarbamoylamino)phenyl]carbamoyl]benzamide
[Molecular Formula]

C17H15ClF2N4O4
[MDL Number]

MFCD22050364
[MOL File]

648926-15-2.mol
[Molecular Weight]

412.78
Chemical PropertiesBack Directory
[density ]

1.490±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMF:5.0(Max Conc. mg/mL);12.11(Max Conc. mM)
DMSO:5.0(Max Conc. mg/mL);12.11(Max Conc. mM)
[form ]

White powder solid.
[pka]

8.47±0.46(Predicted)
[color ]

white
Hazard InformationBack Directory
[Description]

Glycogen phosphorylase in the liver, muscle, and brain initiate glycogenolysis by releasing glucose-1-phosphate from glycogen. Glycogen phosphorylase inhibitor is a cell-permeable acyl urea first identified as an inhibitor of human liver glycogen phosphorylase (IC50 = 53 nM). It blocks glucagon-induced hepatic glycogenolysis in vivo. Glycogen phosphorylase inhibitor has been used to study glycogen utilization in human liver HepG2 cells, retinal explants, and human T lymphocyte Kit 225 cells.
[Uses]

Glycogen Phosphorylase Inhibitor is used in biological studies to evaluate glycogen utilization in human liver HepG2 cells.
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