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ChemicalBook--->CAS DataBase List--->635287-26-2

635287-26-2

635287-26-2 Structure

635287-26-2 Structure
IdentificationBack Directory
[Name]

FMoc-NH-5(ethylene glycol)-acetic acid
[CAS]

635287-26-2
[Synonyms]

FMoc-NH-PEG5-CH2COOH
Fmoc-PEG5-acetic acid
Fmoc-NH-5(ethylene glycol)-actic acid
FMoc-NH-5(ethylene glycol)-acetic acid
1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16,19-hexaoxa-4-azahenicosan-21-oic acid
17-[(9-Fluorenylmethoxycarbonyl)amino]-3,6,9,12,15-pentaoxaheptadecanoic acid
5,8,11,14,17-Pentaoxa-2-azanonadecanedioic acid 1-(9H-fluoren-9-ylmethyl) ester
{2-[2-(2-{2-[2-(9H-fluoren-9-yl-methoxycarbonylamino)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}acetic acid
[Molecular Formula]

C27H35NO9
[MDL Number]

MFCD26142982
[MOL File]

635287-26-2.mol
[Molecular Weight]

517.57
Chemical PropertiesBack Directory
[Boiling point ]

704.3±60.0 °C(Predicted)
[density ]

1.224±0.06 g/cm3(Predicted)
[storage temp. ]

Sealed in dry,2-8°C
[form ]

Viscous Liquid
[pka]

3.39±0.10(Predicted)
[color ]

Colorless to light yellow
Hazard InformationBack Directory
[Description]

Fmoc-NH-PEG5-CH2COOH is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
[Biological Activity]

Fmoc-NH-PEG5-CH2COOH is a degradable ADC linker for antibody drug conjugate (ADC) synthesis. It is also a PEG-based PROTAC linker, which can be used for PROTAC synthesis.
[in vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[target]

Cleavable

Alkyl/ether

PEGs

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