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ChemicalBook--->CAS DataBase List--->63388-44-3

63388-44-3

63388-44-3 Structure

63388-44-3 Structure
IdentificationBack Directory
[Name]

SJB2-043
[CAS]

63388-44-3
[Synonyms]

SJB2-043
2-Phenylnaphth[2,3-d]oxazole-4,9-dione
Naphth[2,3-d]oxazole-4,9-dione, 2-phenyl-
2-phenylbenzo[f][1,3]benzoxazole-4,9-dione
[Molecular Formula]

C17H9NO3
[MDL Number]

MFCD26960957
[MOL File]

63388-44-3.mol
[Molecular Weight]

275.26
Questions And AnswerBack Directory
[Description]

SJB2-043 is a potent USP1 inhibitor that inhibits the activity of native USP1/UAF1 with IC50 of 544 nM.
Chemical PropertiesBack Directory
[Melting point ]

>290℃
[Boiling point ]

495.0±48.0 °C(Predicted)
[density ]

1.373±0.06 g/cm3(Predicted)
[storage temp. ]

Sealed in dry,Room Temperature
[solubility ]

insoluble in H2O; insoluble in EtOH; ≥4.62 mg/mL in DMSO
[form ]

solid
[pka]

-3.87±0.20(Predicted)
[color ]

Green to dark green
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319
[Precautionary statements ]

P261-P305+P351+P338
Spectrum DetailBack Directory
[Spectrum Detail]

SJB2-043(63388-44-3)MS
Hazard InformationBack Directory
[Biological Activity]

sjb2-043 is a novel and potent inhibitor of usp1 with ic50 value of 0.544 μm [1].ubiquitin-specific protease 1 (usp1) is a deubiquitinating enzyme (dub) and is a member of the ubiquitin-specific processing (ubp) family of proteases. it deubiquitinates a protein in the dna repair pathway of the fanconi anemia (fa) [1].in the k562 cell line, sjb2-043 decreased usp1 levels in a dose-dependent way and caused degradation of the id1 protein, which resulted from proteasomal degradation. also, sjb2-043 decreased the levels of id2 and id3 proteins. importantly, knockdown of usp1 inhibited cell growth and increased apoptosis. in primary aml cells, sjb2-043 inactivated usp1 and promoted id 1 degradation. in primary human cord blood cd34+ cells, sjb2-043 in low micromolar levels inhibited cell growth. in hela cells, sjb2-043 increased the levels of ub-fancd2 and ub-pcna. and deubiquitination of fancd2 is an important step in the brca/fanconi anemia (fa) dna repair pathway [1].
[References]

[1]. helena mistry, grace hsieh, sara s, et al. buhrlage, et al. small molecule inhibitors of usp1 target id1 degradation in leukemic cells. mol cancer ther, 2013, 12(12): 2651-2662.
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