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Crenulatin is a gallotannin that can be isolated from Rhodiola rosea. Crenulatin can be used as a biomarker to identify potentially adulterated R. rosea products. Crenulatin has dual- direction effects on apoptosis of cerebral microvascular endothelial cells, via regulating Fas/Bcl-2 expression and caspase-3 activity[1][2][3]. | [References]
[1] Marchev AS, et al. Authenticity and quality evaluation of different Rhodiola species and commercial products based on NMR-spectroscopy and HPLC. Phytochem Anal. 2020 Nov;31(6):756-769. DOI:10.1002/pca.2940
[2] W S Yu, et al. Polyphenols from Rhodiola crenulata. Planta Med. 1993 Feb;59(1):80-2. DOI:10.1055/s-2006-959610
[3] Qian R, et al. Dual-direction effect of crenulatin on apoptosis of cerebral microvascular endothelial cells and it's mechanism[J]. Chinese Journal of Pathophysiology, 2005: 2086-2090. |
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