| Identification | Back Directory | [Name]
1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl cyclopropanecarboxylate hydrochloride(WXC08998) | [CAS]
627085-15-8 | [Synonyms]
OT-551
OT-551 HCl
1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl cyclopropanecarboxylate hydrochloride
1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl cyclopropanecarboxylate hydrochloride(WXC08998) | [Molecular Formula]
C13H24ClNO3 | [MDL Number]
MFCD14105606 | [MOL File]
627085-15-8.mol | [Molecular Weight]
277.788 |
| Hazard Information | Back Directory | [Uses]
OT-551 is a NF-κB inhibitor with antioxidant and anti-inflammatory effects. OT-551 has the potential for retinal diseases research[1][2]. | [in vivo]
OT-551 (25-100 mg/kg; ip; once) provides RPE cell protection against acute light damage in albino rats[1]. | Animal Model: | Sprague-Dawley (SD) albino rats (6-7 weeks of age) exposure to 2700 lux white fluorescent light[1] | | Dosage: | 25, 50, or 100 mg/kg | | Administration: | ip; once | | Result: | Retinal pigment epithelium (RPE) damage index was significantly lower in the animals.
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| [References]
[1] Masaki Tanito, et al. Protection of retinal pigment epithelium by OT-551 and its metabolite TEMPOL-H against light-induced damage in rats. Exp Eye Res. 2010 Jul;91(1):111-4. DOI:10.1016/j.exer.2010.04.012
[2] S. A. Mousa, et al. Anti-Angiogenesis Efficacy of the Novel NF-B and Oxidative Stress Inhibitor, OT-551. ARVO Annual Meeting Abstract. |
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