| Identification | Back Directory | [Name]
PEG10-Tos | [CAS]
62573-11-9 | [Synonyms]
Tos-PEG9
PEG10-Tos
Peg10-ots
OH-PEG9-Tos
Tos-PEG9-OH
HO-(CH2CH2O)9-Tos
26-Hydroxy-3,6,9,12,15,18,21,24-octaoxahexacosyl 4-methylbenzenesulfonate
3,6,9,12,15,18,21,24-Octaoxahexacosane-1,26-diol, 1-(4-methylbenzenesulfonate) | [Molecular Formula]
C25H44O12S | [MDL Number]
MFCD27977527 | [MOL File]
62573-11-9.mol | [Molecular Weight]
568.67 |
| Hazard Information | Back Directory | [Description]
PEG10-Tos is a PEG linker containing a hydroxyl group with a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The tosyl group is a very good leaving group for nucleophilic substitution reactions. | [Uses]
Tos-PEG9 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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