| Identification | Back Directory | [Name]
11-KETO FLUPROSTENOL | [CAS]
62145-07-7 | [Synonyms]
11-KETO FLUPROSTENOL
Travoprost Impurity 22
FLUPROSTENOL PROSTAGLANDIN D2
Travoprost Impurity 17（11-keto Fluprostenol）
11-OXO-9ALPHA,15R-DIHYDROXY-16-(3-(TRIFLUOROMETHYL)PHENOXY)-17,18,19,20-TETRANOR-PROSTA-5Z,13E-DIEN-1-OIC ACID | [Molecular Formula]
C23H27F3O6 | [MDL Number]
MFCD05863541 | [MOL File]
62145-07-7.mol | [Molecular Weight]
456.45 |
| Hazard Information | Back Directory | [Description]
11-keto Fluprostenol is an analog of prostaglandin D2 (PGD2) with structural modifications intended to give it a prolonged half-life and greater potency. Fluprostenol is a well-studied, potent analog of PGF2α and acts primarily through the FP receptor.1 Oxidation at C-11 of fluprostenol yields 11-keto fluprostenol. 11-keto Fluprostenol exhibits moderate binding to the CRTH2/DP2 receptor compared to PGD2 and essentially no activity at the DP1 receptor.2 | [Definition]
ChEBI: 11-keto Fluprostenol is a prostanoid. | [References]
1. Dukes, M., Russell, W., and Walpole, A.L. Potent luteolytic agents related to prostaglandin F2α Nature 250(464),330-331(1974).
2. Monneret, G., Cossette, C., Gravel, S., et al. 15R-methyl-prostaglandin D2 is a potent and selective CRTH2/DP2 receptor agonist in human eosinophils J. Pharmacol. Exp. Ther. 304(1),349-355(2003). |
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