| Identification | Back Directory | [Name]
4-[3-(6-METHYL-2-PYRIDINYL)-1H-PYRAZOL-4-YL]-QUINOLINE | [CAS]
607737-87-1 | [Synonyms]
A77-01
A 77-01
A-77-01
CS-1775
A7701;A 7701; A-7701
4-[3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl]quinoline
4-[3-(6-METHYL-2-PYRIDINYL)-1H-PYRAZOL-4-YL]-QUINOLINE
4-[5-(6-methylpyridin-2-yl)-1~{H}-pyrazol-4-yl]quinoline
Quinoline, 4-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-
4-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]quinoline A 77-01 | [Molecular Formula]
C18H14N4 | [MDL Number]
MFCD07367791 | [MOL File]
607737-87-1.mol | [Molecular Weight]
286.33 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
insoluble in H2O; ≥14.3 mg/mL in DMSO; ≥8.84 mg/mL in EtOH with gentle warming and ultrasonic | [form ]
solid | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
A 77-01 is a potent inhibitor of transforming growth factor (TGF)-β type I receptor superfamily activin-like kinase ALK5 with an IC50 of 25 nM[1]. | [storage]
Store at +4°C | [References]
[1] Tojo M, et al. The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta. Cancer Sci. 2005 Nov;96(11):791-800. DOI:10.1111/j.1349-7006.2005.00103.x |
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BOC Sciences
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Shanghai Uchem Inc.
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SPIRO PHARMA
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www.spiropharma.com.cn |
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