| Identification | Back Directory | [Name]
LOBEGLITAZONE | [Synonyms]
LOBEGLITAZONE
2,4-Thiazolidinedione, 5-[[4-[2-[[6-(4-methoxyphenoxy)-4-pyrimidinyl]methylamino]ethoxy]phenyl]methyl]-
5-[[4-[2-[[6-(4-methoxyphenoxy)pyrimidin-4-yl]-methylamino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
(5R)-5-[[4-[2-[[6-(4-methoxyphenoxy)pyrimidin-4-yl]-methylamino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione | [Molecular Weight]
480.54 |
| Hazard Information | Back Directory | [Definition]
ChEBI: Lobeglitazone is an aromatic ether. | [in vivo]
Lobeglitazone (1-10 mg/kg, po for 8 weeks) exhibits anti-atherosclerotic property in ApoE?/? mouse models[4].
| Animal Model: | ApoE?/? mouse aortic atherosclerosis models[4] | | Dosage: | 1-10 mg/kg | | Administration: | po for 8 weeks | | Result: | Reduced aortic arch plaques. |
| [IC 50]
PPARγ: 137.4 nM (EC50); PPARα: 546.3 nM (EC50) |
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| Company Name: |
LGM Pharma
|
| Tel: |
1-(800)-881-8210 |
| Website: |
www.lgmpharma.com |
|