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ChemicalBook--->CAS DataBase List--->60762-57-4

60762-57-4

60762-57-4 Structure

60762-57-4 Structure
IdentificationBack Directory
[Name]

2,3,3A,4,5,6-HEXAHYDRO-8-METHYL-1H-PYRAZINO[3,2,1-J,K]CARBAZOLE MESYLATE
[CAS]

60762-57-4
[Synonyms]

Pirlindol
Pyrazidol
Pirlindole
Pirlindolum
Unii-V39yph45fz
PIRLINDOLE MESYLATE
Pirlindole free base
Pirlindolum [inn-latin]
16154-78-2 (Hydrochloride)
Pirlindol [inn-spanish, french]
2,3,3a,4,5,6-Hexahydro-8-methyl-1H-pyrazino[3,2,1-jk]carbazole
8-Methyl-2,3,3a,4,5,6-hexahydro-1H-pyrazino[3,2,1-jk]carbazole
1H-Pyrazino[3,2,1-jk]carbazole,2,3,3a,4,5,6-hexahydro-8-methyl-
2,3,3A,4,5,6-HEXAHYDRO-8-METHYL-1H-PYRAZINO[3,2,1-J,K]CARBAZOLE MESYLATE
8-Methyl-2,3,3a,4,5,6-hexahydro-1H-pyrazino-[3,2,1-jk]carbazole methanesulfonate
[Molecular Formula]

C15H18N2
[MDL Number]

MFCD00407230
[MOL File]

60762-57-4.mol
[Molecular Weight]

226.32
Chemical PropertiesBack Directory
[storage temp. ]

Store at RT
[solubility ]

DMF: 1 mg/ml; DMSO: 5 mg/ml
[form ]

A crystalline solid
[color ]

Off-white to light yellow
Safety DataBack Directory
[HazardClass ]

IRRITANT
Hazard InformationBack Directory
[Description]

Pirlindole is a selective and reversible monoamine oxidase A (MAO-A) inhibitor (IC50s = 250 and 34.2 nM for rat brain and heart MAO-A, respectively). It is selective for MAO-A over MAO-B (Kis = 52,100 and 59,900 nM, for rat brain and heart MAO-B, respectively). In rats, it reverses the depressive-like effects induced by chronic mild stress (CMS), increases proliferation of hippocampal neural progenitor cells, and reverses dendritic atrophy in granule neurons. Pirlindole is also an inhibitor of enterovirus-D68 and coxsackievirus B3 (CV-B3), inhibiting the genome replication phase of CV-B3 infection with an EC50 value of 7.7 μM independent of MAO-A activity.
[Uses]

Antidepressive;Monoamine oxidase inhibitor
[Biological Activity]

A highly selective reversible inhibitor of monoamine oxidase type A.
[storage]

Store at -20°C
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