| Identification | Back Directory | [Name]
(3a,5b,7a,12a)-3,12-dihydroxy-7-(sulfooxy)-Cholan-24-oic acid | [CAS]
60320-05-0 | [Synonyms]
7-Sulfocholic acid
Cholic Acid 7-sulfate
Cholic Acid 7-sulfate (7-SCA)
(3a,5b,7a,12a)-3,12-dihydroxy-7-(sulfooxy)-Cholan-24-oic acid
Cholan-24-oic acid, 3,12-dihydroxy-7-(sulfooxy)-, (3α,5β,7α,12α)- | [Molecular Formula]
C24H40O8S | [MOL File]
60320-05-0.mol | [Molecular Weight]
488.63 |
| Chemical Properties | Back Directory | [density ]
1.33±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 1 mg/ml; DMSO: 0.3 mg/ml; PBS (pH 7.2): 1 mg/ml | [form ]
A crystalline solid | [pka]
-3.54±0.18(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Cholic acid 7-sulfate is a metabolite of the primary bile acid cholic acid . It is produced by conjugation of a sulfate group with the hydroxy group at position 7 of cholic acid in the liver and gut. Fecal levels of cholic acid 7-sulfate are increased in male, but not female, mice fed a diet supplemented with cholic acid or chenodeoxycholic acid . | [Uses]
Cholic acid 7-sulfate (7-Sulfocholic acid), a metabolite of Cholic acid, is a Takeda G-protein receptor 5 (TGR5) agonist. Cholic acid 7-sulfate can increase Tgr5 expression and induce GLP-1 secretion[1]. | [Definition]
ChEBI: 7-Sulfocholic acid is a cholanoid. It is a conjugate acid of a cholate 7-sulfate(2-). | [storage]
Store at -20°C | [References]
[1] Chaudhari SN, et, al. Bariatric surgery reveals a gut-restricted TGR5 agonist with anti-diabetic effects. Nat Chem Biol. 2021 Jan;17(1):20-29. DOI:10.1038/s41589-020-0604-z |
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