| Identification | Back Directory | [Name]
4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID | [CAS]
59662-49-6 | [Synonyms]
8BCA
AC 55649
RARECHEM AL BO 1323
4-(4-Octylphenyl)-benzoic acid
4'-OCTYL-4-BIPHENYLCARBOXYLIC ACID
4-OCTYL-4'-BIPHENYLCARBOXYLIC ACID
4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID
4-N-OCTYLBIPHENYL-4'-CARBOXYLIC ACID
4-Octyl-4'-biphenylcarboxylic acid
4'-OCTYL-[1,1'-BIPHENYL]-4-CARBOXYLIC ACID
[1,1'-Biphenyl]-4-carboxylic acid, 4'-octyl-
4′-Octyl-4-biphenylcarboxylic acid, 4′-n-octylbiphenyl-4-carboxylic acid | [Molecular Formula]
C21H26O2 | [MDL Number]
MFCD00157040 | [MOL File]
59662-49-6.mol | [Molecular Weight]
310.43 |
| Chemical Properties | Back Directory | [Melting point ]
148-152 °C(Solv: dichloromethane (75-09-2)) | [Boiling point ]
462.0±34.0 °C(Predicted) | [density ]
1.037±0.06 g/cm3(Predicted) | [storage temp. ]
Store at +4°C | [solubility ]
DMSO: >7mg/mL | [form ]
solid | [pka]
4.23±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
AC 55649 is a potent and selective RARβ2 receptor agonist (1). RARβ2 receptor agonists are potential drug candidates for developing treatment for type 2 diabetes and hepatic steatosis (2). | [Definition]
ChEBI: 4-(4-octylphenyl)benzoic acid is a member of biphenyls and a carboxybiphenyl. | [Biological Activity]
Potent, isoform-selective RAR β 2 receptor agonist (pEC 50 values are 6.9, 5.7 and 5.6 at RAR β 2, RAR β 1 and RAR α respectively) that displays 100-fold selectivity versus other retinoid receptors. Inhibits proliferation of the breast cancer cell line MCF-7. | [Biochem/physiol Actions]
AC-55649 is a subtype selective RAR (RARβ2) agonist. AC-55649 is a potent, orally available isoform selective Retinoic Acid Receptor β2. AC-55649 has high selectivity, 99% for RARβ2 and 31% for RARβ1. When compared to the gold standard AM-580 (Cat. No A8843), both isoform receptors were 100%. AC-55649 has a potent EC50 of 6.9 μM compared to an EC50 of 7.7 μM for AM-580. |
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