| Identification | Back Directory | [Name]
CDAP | [CAS]
59016-56-7 | [Synonyms]
CDAP
N-Cyano-4-diMethylaMinopyridiniuM tetrafluoroborat
N-CYANO-4-DIMETHYLAMINOPYRIDINIUM TETRA FLUOROBORATE
1-CYANO-4-DIMETHYLAMINO-PYRIDINIUM TETRAFLUOROBORATE
CDAP N-Cyano-4-dimethylaminopyridinium tetrafluoroborate
1-Cyano-4-dimethylaminopyridinium tetrafluoroborate,97+%
4-(DiMethylaMino)pyridin-1-iuM-1-carbonitriletetrafluoroborate | [Molecular Formula]
C8H10BF4N3 | [MDL Number]
MFCD00011998 | [MOL File]
59016-56-7.mol | [Molecular Weight]
234.99 |
| Chemical Properties | Back Directory | [Appearance]
White to yellow powder | [Melting point ]
196-200°C | [storage temp. ]
2-8°C
| [form ]
Powder | [color ]
White to yellow | [biological source]
synthetic | [Water Solubility ]
Soluble in water, and acetonitrile. | [λmax]
301nm(CH3CN)(lit.) | [BRN ]
5685616 |
| Hazard Information | Back Directory | [Chemical Properties]
White to yellow powder | [Uses]
1-Cyano-4-(dimethylamino)pyridinium tetrafluoroborate is a cyanylation reagent for protein sulfhydryl groups and used to prepare protein-polysaccharide conjugates. It is employed as an activating agent for polysaccharide resins and conjugation of lipopolysaccharides while retaining endotoxic activity. | [Biological Activity]
CDAP is a cyanylation reagent for protein sulfhydryl groups which is used to prepare protein-polysaccharide conjugates. CDAP is also an activating agent for polysaccharide resins and is used for the conjugation of lipopolysaccharides while retaining their endotoxic activity.
CDAP is considered to be a less toxic reagent as compared to cyanogen bromide (CNBr) (a known polysaccharides activator). In additionCDAP is easier to use as it can be employed at a lower pH and has fewer side reactions. It is known th at CDAP polysaccharide activation efficiency is optimal at pH 9-10. It was also reported th at direct conjugation of protein to CDAP-activated polysaccharides can be performed under mildly alkaline conditions (pH 7-9). It has also been reported th at proteins could also be conjugated to CDAP-activated polysaccharides at pH 5. |
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