| Identification | Back Directory | [Name]
Chloropyramine | [CAS]
59-32-5 | [Synonyms]
Synpen
Synopen
Avapena
Allergan
synopenr
Synopen R
Suprastin
allergans
Allergan S
Anaphylline
Halopyramine
Chlorpyramine
CHLOROPYRAMINE
Chlorneoantergan
Chloroneoantergan
Chloropyribenzamine
CHLOROPYRAMINE BASE
Chloropyramine USP/EP/BP
p-Chlorbenzyl-alpha-pyridyl-dimethyl-aethylendiamin
2-[(4-chlorobenzyl)[2-(dimethylamino)ethyl]amino]pyridine
2-((p-chlorobenzyl)(2-(dimethylamino)ethyl)amino)-pyridin
2-((p-Chlorobenzyl)(2-(dimethylamino)ethyl)amino)pyridine
Pyridine, 2-((p-chlorobenzyl)(2-(dimethylamino)ethyl)amino)-
n-(p-chlorobenzyl)-n’,n’-dimethyl-n-(2-pyridyl)-ethylenediamin
n-(p-chlorobenzyl)-n',n'-dimethyl-n-(2-pyridyl)ethylenediamine
Ethylenediamine, N-(p-chlorobenzyl)-N',N'-dimethyl-N-(2-pyridyl)-
n-((4-chlorophenyl)methyl)-n’,n’-dimethyl-n-2-pyridinyl-2-ethanediamine
N'-[(4-chlorophenyl)methyl]-N,N-dimethyl-N'-pyridin-2-ylethane-1,2-diamine
1,2-Ethanediamine, N-[(4-chlorophenyl)methyl]-N',N'-dimethyl-N-2-pyridinyl-
1,2-Ethanediamine, N1-[(4-chlorophenyl)methyl]-N2,N2-dimethyl-N1-2-pyridinyl- | [EINECS(EC#)]
200-421-1 | [Molecular Formula]
C16H20ClN3 | [MDL Number]
MFCD00065266 | [MOL File]
59-32-5.mol | [Molecular Weight]
289.8 |
| Hazard Information | Back Directory | [Uses]
Chloropyramine is used for allergic dermatosis, allergic rhinitis and conjunctivitis, for
drug-induced allergies, in the beginning stages of bronchial asthma, eczema, neurodermatitis,
contact dermatitis, and toxicodermia. It also exhibits a sedative effect. Synonyms
of this drug are suprastin, chlortripelenamine, and synopen. | [Definition]
ChEBI: N'-[(4-chlorophenyl)methyl]-N,N-dimethyl-N'-(2-pyridinyl)ethane-1,2-diamine is an aminopyridine. | [Synthesis]
Chloropyramine, N-(4-chlorobenzyl)-N??,N??-dimethyl-N-2-pyridylethylenediamine
(16.1.9), is synthesized in a somewhat different manner, which is by reacting
2-brompyridine with N-(4-chlorobenzyl)-N??,N??-dimethylethylenediamine (16.1.8).
N-(4-Chlorobenzyl)-N??,N??-dimethylethylenediamine (16.1.8), in turn, is synthesized by
condensation of 4-chlorobenzaldehyde c N,N-dimethylethylenediamine with subsequent
reduction of the imine group.
| [in vivo]
Chloropyramine (i.p.; 10 mg/kg) abolishes hypothermia in rats[2]. | Animal Model: | Rats[2] | | Dosage: | 10 mg/kg | | Administration: | Intraperitoneal | | Result: | Reduced histamine-induced hypothermia. |
| [IC 50]
H1 Receptor |
|
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BOC Sciences
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Hubei Baidu Chemical Co., Ltd
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