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ChemicalBook--->CAS DataBase List--->5890-18-6

5890-18-6

5890-18-6 Structure

5890-18-6 Structure
IdentificationBack Directory
[Name]

LAUROLITSINE
[CAS]

5890-18-6
[Synonyms]

Norboldine
Aids161652
Aids-161652
Laurolistine
Laurolitsine
Norisoboidine
1,10-Dimethoxy-6aα-noraporphine-2,9-diol
(S)-5,6,6a,7-Tetrahydro-1,10-dimethoxy-4H-dibenzo[de,g]quinoline-2,9-diol
(6aS)-5,6,6a,7-Tetrahydro-1,10-dimethoxy-4H-dibenzo[de,g]quinoline-2,9-diol
4H-Dibenzo[de,G]quinoline-2,9-diol, 5,6,6A,7-tetrahydro-1,10-dimethoxy-, (6as)-
[Molecular Formula]

C18H19NO4
[MDL Number]

MFCD06809897
[MOL File]

5890-18-6.mol
[Molecular Weight]

313.351
Chemical PropertiesBack Directory
[Melting point ]

138-140 ºC
[Boiling point ]

453.15°C (rough estimate)
[density ]

1.313
[refractive index ]

1.5100 (estimate)
[solubility ]

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
[form ]

Cryst.
[pka]

9.81±0.20(Predicted)
[color ]

Off-white to pink
Hazard InformationBack Directory
[Description]

This noraporphiae alkaloid has been obtained from Litsea japonica and Neolitsea sericea and swells at 11 5-8°C before melting. It is dextrorotatory with [o:lbl + 102.5° (EtOH) and yields a picrate as yellow needles, m.p. 212°C (dec.) and a picrolonate, m.p. 239°C (dec.). The N-methyl derivative is identical with boldine.
[Uses]

Laurolitsine is an alkaloid extracted from Polyalthia longifolia var. pendula.
[Definition]

ChEBI: An isoquinoline alkaloid that is noraporphine substituted by hydroxy groups at positions 2 and 9 and methoxy groups at positions 1 and 10. Isolated from Litsea glutinosa and Lindera chunii, exhibits inhibitory activity against HIV 1 integrase.
[References]

Nakasato, Nomura., Chem. Pharm. Bull., (Tokyo), 7, 780 (1959)
Kozuka., J. Ph arm. Soc., Japan, 82, 1567 (1962)
See also:
Johns, Lamberton., Austral. J. Chem., 20, 1277 (1967)
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