| Identification | Back Directory | [Name]
2-Benzofurancarboxamide,3-methyl-N-[4-(trifluoromethyl)phenyl]-(9CI) | [CAS]
588674-64-0 | [Synonyms]
CCR6 antagonist 1
2-Benzofurancarboxamide, 3-methyl-N-[4-(trifluoromethyl)phenyl]-
2-Benzofurancarboxamide,3-methyl-N-[4-(trifluoromethyl)phenyl]-(9CI) | [Molecular Formula]
C17H12F3NO2 | [MOL File]
588674-64-0.mol | [Molecular Weight]
319.28 |
| Chemical Properties | Back Directory | [Boiling point ]
345.9±42.0 °C(Predicted) | [density ]
1.358±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 100 mg/mL (313.20 mM) | [form ]
Solid | [pka]
12.24±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
CCR6 antagonist 1 is a CCR6 antagonist that inhibits the CCL20/CCR6 axis. CCR6 antagonist 1 can be used in the research of autoimmune-mediated inflammatory diseases, such as inflammatory bowel diseases (IBDs)[1]. | [in vivo]
CCR6 antagonist 1 (compound 1b, 1 mg/kg, s.c., twice daily for 3 days) alleviates TNBS-induced inflammatory responses in mice[1].
?
CCR6 antagonist 1 (1 mg/kg, s.c., twice, before and after zymosan treatment) shows anti-inflammatory effects
in Zymosan-induced peritonitis mice[1].
| Animal Model: | Murine model of colitis (5 mg/mouse TNBS-induced)[1] | | Dosage: | 1 mg/kg | | Administration: | Subcutaneous injection (s.c.), twice daily for 3 days. | | Result: | Improved mice general conditions, attenuated macroscopic injury and counteracted neutrophils infiltration, both in the colon and in lungs. |
| Animal Model: | Zymosan-induced peritonitis mice[1] | | Dosage: | 1 mg/kg | | Administration: | Subcutaneous injection (s.c.), twice, before and after zymosan treatment | | Result: | Significantly reduced the total protein content and myeloperoxidase activity in the peritoneal lavage. |
| [IC 50]
CCR6 | [References]
[1] Maria Grazia Martina, et al. Discovery of small-molecules targeting the CCL20/CCR6 axis as first-in-class inhibitors for inflammatory bowel diseases. Eur J Med Chem. 2022 Aug 29;243:114703. DOI:10.1016/j.ejmech.2022.114703 |
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| Company Name: |
InvivoChem
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| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
| Company Name: |
CHEMSTEP
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| Tel: |
33 (0) 556 405 186 |
| Website: |
www.chemstep.com |
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