| Identification | Back Directory | [Name]
Isoquinoline, 5-iodo- (9CI) | [CAS]
58142-99-7 | [Synonyms]
Isoquinoline, 5-iodo-
Isoquinoline, 5-iodo- (9CI) | [EINECS(EC#)]
604-604-1 | [Molecular Formula]
C9H6IN | [MDL Number]
MFCD11226893 | [MOL File]
58142-99-7.mol | [Molecular Weight]
255.06 |
| Chemical Properties | Back Directory | [Boiling point ]
336.8±15.0 °C(Predicted) | [density ]
1.837±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [solubility ]
Ethanol:25.51(Max Conc. mg/mL);100.0(Max Conc. mM)
DMSO:25.51(Max Conc. mg/mL);100.0(Max Conc. mM) | [form ]
solid | [pka]
4.48±0.13(Predicted) | [color ]
Yellow to brown |
| Hazard Information | Back Directory | [Biological Activity]
DSRM-3716 is a potent and selective SARM1 NADase inhibitor (NAD+ hydrolysis IC50 = 75 nM using recombinant SARM1 SAM-TIR construct) th at recapitulates the SARM1-/- phenotype and protects axons from degeneration induced by axotomy (EC50 = 2.1/1.9 μM by fragmentation/NfL release using mouse DRG neurons; 81/88% protection by 1/3 μM DSRM-3716 using human iPSC-derived motor neurons) or mitochondrial dysfunction (3-30 μM DSRM-3716 against 25 μM rotenone-induced injury; mouse DRG neurons). MechanisticallyDSRM-3716 undergoes base exchange with the nicotinamide (NAM) moiety of nicotinamide adenine dinucleotide (NAD+) to yield the bona fide inhibitor 1AD. | [storage]
4°C, protect from light |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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