| Identification | Back Directory | [Name]
Centhaquine | [CAS]
57961-90-7 | [Synonyms]
PMZ-2010
Centhaquin
Centhaquine
Centhaquin PMZ-2010
Centhaquin >=98% (HPLC)
Centhaquin (Centhaquine,PMZ-2010)
2-[2-[4-(3-Methylphenyl)-1-piperazinyl]ethyl]quinoline
Quinoline, 2-[2-[4-(3-methylphenyl)-1-piperazinyl]ethyl]- | [Molecular Formula]
C22H25N3 | [MOL File]
57961-90-7.mol | [Molecular Weight]
331.45 |
| Hazard Information | Back Directory | [Uses]
Centhaquin is a centrally acting hypotensive drug similar to Clonidine (C587120), which is an α2 adrenergic agonist. | [Biological Activity]
Centhaquin is a centrally acting hypotensive agent. Centhaquin is an effective resuscitative agent th at improves cardiac outputreduces blood lactate levelsand improves survival time of hemorrhaged rats. Centhaquin exhibits antinociception in the mouse mediated through the opioidthe α2A and α2B adrenoceptors. | [in vivo]
Centhaquine (Centhaquin) (intravenous injection, 0.01-1.0 mg/kg; intraduodenal administration 1.0-2.5 mg/kg) lowers the blood pressure and reduced the heart rate of anaesthetized and unanaesthetized (decerebrate) cat in a dose-dependent manner[1].
Centhaquine (Centhaquin) (intravertebral arterial injection; 5-10 μg) or by topical application to the exposed ventral surface of medulla or floor of the fourth ventricle causes hypotension and bradycardia as well as reduced the excitability of the vasomotor loci[1].
Centhaquine (Centhaquin;PMZ-2010) (intravenous administration; 0.015mg/kg) can attenuate the deleterious effects of catecholamines, improving both the macro- and microcirculation during CPR[2]. | Animal Model: | Landrace/Large White piglets[2] | | Dosage: | 0.015mg/kg | | Administration: | Intravenous administration; Adrenaline 0.02mg/kg plus Centhaquin 0.015mg/kg | | Result: | Added to adrenaline improved ROSC rates in a swine model of VF cardiac arrest. |
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