| Identification | Back Directory | [Name]
1,2,3,4,8,9,10,11-OCTAHYDRO[1,4]DIAZEPINO[6,7,1-JK]CARBAZOLE HYDROCHLORIDE | [CAS]
57756-45-3 | [Synonyms]
WAY 629 hydrochlorid
WAY 629 HYDROCHLORIDE
4,5,6,7,9,10,11,12-Octahydro[1,4]diazepino[6,7,1-jk]carbazole
[1,4]Diazepino[6,7,1-jk]carbazole, 4,5,6,7,9,10,11,12-octahydro-
1,2,3,4,8,9,10,11-OCTAHYDRO[1,4]DIAZEPINO[6,7,1-JK]CARBAZOLE HYDROCHLORIDE | [Molecular Formula]
C15H18N2 | [MDL Number]
MFCD06798323 | [MOL File]
57756-45-3.mol | [Molecular Weight]
226.32 |
| Hazard Information | Back Directory | [Uses]
WAY 629 is a selective SR-2C agonist. Potent and efficacious 5-HT2C receptor agonists. | [Definition]
ChEBI: LSM-3233 is a member of carbazoles. | [Biological Activity]
Selective 5-HT 2C agonist. K i values are 56, 2350, 1575 and 815 nM for human recombinant 5-HT 2C , 5-HT 2A , 5-HT 6 and 5-HT 7 receptors respectively. Stimulates intracellular Ca 2+ mobilization in CHO cells expressing human 5-HT 2C receptors (EC 50 = 72 nM). Reduces food intake in rats. | [in vivo]
WAY 629 (30 mg/kg; i.p.) decreases feeding behavior in rats[1].
WAY 629 (21 mg/kg; i.p.) decreases the expression of NPY mRNA in mice brains[2]. | Animal Model: | WT mice[2] | | Dosage: | 21 mg/kg | | Administration: | I.p. | | Result: | Decreased the expression of NPY mRNA. |
| [IC 50]
5-HT2C Receptor: 426 nM (EC50); 5-HT2A Receptor: 260000 nM (EC50) |
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