| Identification | Back Directory | [Name]
1,4,7-triazacyclononane-N,N',N''-triacetic acid | [CAS]
56491-86-2 | [Synonyms]
NOTA
NOTA(M-600)
1,4,7-triazacyclononane-N,N',N''-triacetic acid
Octahydro-1H-1,4,7-triazonine-1,4,7-triacetic Acid
1H-1,4,7-Triazonine-1,4,7-triaceticacid, hexahydro-
2,2',2''-(1,4,7-Triazonane-1,4,7-triyl)triacetic acid
2-[4,7-bis(carboxymethyl)-1,4,7-triazonan-1-yl]acetic acid
2,2',2''-(1,4,7-triazacyclononane-1,4,7-triyl)triacetic acid
1H-1,4,7-Triazonine-1,4,7-triacetic acid, hexahydro-56491-86-2
2-[4,7-bis(carboxymethyl)-1,4,7-triazonan-1-yl]acetic acid
NOTA
1, 4, 8, 11-Tetraazabicyclo[6.6. 2]hexadecane-4, 11-diacetic acid | [Molecular Formula]
C12H21N3O6 | [MDL Number]
MFCD00137938 | [MOL File]
56491-86-2.mol | [Molecular Weight]
303.31 |
| Chemical Properties | Back Directory | [Boiling point ]
572.9±50.0 °C(Predicted) | [density ]
1.321±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C, protect from light | [form ]
Solid | [pka]
1.82±0.10(Predicted) | [color ]
White to off-white | [Water Solubility ]
Water : 125 mg/mL (412.12 mM; Need ultrasonic) |
| Hazard Information | Back Directory | [Description]
NOTA is a bifunctional chelating agent that shows high complexation constant with metals, such as gallium. | [Uses]
NOTA is a bifunctional chelate which acts as the framework to construct PET imaging tools. NOTA also can be used for probe design and signal amplification via the multivalent effect. NOTA can be used in multiple myeloma, breast cancer, lymphoma and myocardial infarction research[1][2][3][4][5][6]. | [in vivo]
NOTA participates in the synthesis of [64Cu]NOTA-pentixather to enables high resolution PET imaging of CXCR4 expressionin in Daudi lymphoma-bearing severe combined immunodeficiency (SCID) mice [3].
NOTA participates in the synthesis of 68Ga-NOTA-RGD for MicroPET/CT imaging of αvβ3integrin in rat myocardial infarction[4].
NOTA participates in the synthesis of [68Ga]Ga-NOTA-Nb1053 for immunoPET imaging of multiple myeloma[5].
NOTA is a superior chelator to DOTA for PET imaging with 64Cu-labeled TRC105 in 4T1 murine breast tumor-bearing mice[6].
| [IC 50]
RDC Bifunctional Chelator | [References]
[1] Singh AN, et al. Multivalent bifunctional chelator scaffolds for gallium-68 based positron emission tomography imaging probe design: signal amplification via multivalency. Bioconjug Chem. 2011;22(8):1650-1662. DOI:10.1021/bc200227d
[2] Liao AH, et al. Evaluation of 18F-labeled targeted perfluorocarbon-filled albumin microbubbles as a probe for microUS and microPET in tumor-bearing mice. Ultrasonics. 2013;53(2):320-327. DOI:10.1016/j.ultras.2012.06.014
[3] Poschenrieder A, et al. [64Cu]NOTA-pentixather enables high resolution PET imaging of CXCR4 expression in a preclinical lymphoma model. EJNMMI Radiopharm Chem. 2017;2(1):2. DOI:10.1186/s41181-016-0020-6
[4] Menichetti L, et al. MicroPET/CT imaging of αvβ? integrin via a novel ??Ga-NOTA-RGD peptidomimetic conjugate in rat myocardial infarction. Eur J Nucl Med Mol Imaging. 2013 Aug;40(8):1265-74. DOI:10.1007/s00259-013-2432-9
[5] Wang C, et al. ImmunoPET imaging of multiple myeloma with [68Ga]Ga-NOTA-Nb1053. Eur J Nucl Med Mol Imaging. 2021 Aug;48(9):2749-2760. DOI:10.1007/s00259-021-05218-1
[6] Zhang Y, et al. Positron emission tomography imaging of CD105 expression with a 64Cu-labeled monoclonal antibody: NOTA is superior to DOTA. PLoS One. 2011;6(12):e28005. DOI:10.1371/journal.pone.0028005 |
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