天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

ChemicalBook--->CAS DataBase List--->548472-68-0

548472-68-0

548472-68-0 Structure

548472-68-0 Structure
IdentificationBack Directory
[Name]

NUTLIN-3
[CAS]

548472-68-0
[Synonyms]

CS-390
NUTLIN-3
(?)-NUTLIN-3
Nutlin-3, >=98%
NUTLIN3;NUTLIN 3
Nutlin-3 ((±
NUTLIN-3 (Free base)
MDM2 Antagonist, Nutlin-3, Racemic
MDM2 Antagonist, Nutlin-3, Racemic - CAS 548472-68-0 - Calbiochem
4-(4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbony
4-[4,5-Bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one
4-[4,5-Bis-(4-chloro-phenyl)-2-(2-isopropoxy-4-Methoxy-phenyl)-4,5-dihydro-iMidazole-1-carbonyl]-piperazin-2-one
(+/-)-4-[4,5-BIS(4-CHLOROPHENYL)-2-(2-ISOPROPOXY-4-METHOXY-PHENYL)-4,5-DIHYDRO-IMIDAZOLE-1-CARBONYL]-PIPERAZIN-2-ONE
Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-, rel-
2-Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-, rel-
[EINECS(EC#)]

200-258-5
[Molecular Formula]

C30H30Cl2N4O4
[MDL Number]

MFCD07784509
[MOL File]

548472-68-0.mol
[Molecular Weight]

581.49
Chemical PropertiesBack Directory
[Melting point ]

>132oC (dec.)
[density ]

1.36±0.1 g/cm3(Predicted)
[storage temp. ]

-20°C
[solubility ]

DMSO: 20 mg/mL, soluble
[form ]

solid
[pka]

14.35±0.20(Predicted)
[color ]

White
[Stability:]

Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
[InChIKey]

BDUHCSBCVGXTJM-UHFFFAOYSA-N
Safety DataBack Directory
[Hazard Codes ]

Xi
[Risk Statements ]

36/37/38
[Safety Statements ]

26-36
[WGK Germany ]

3
Hazard InformationBack Directory
[Description]

(±)-Nutlin-3 is a racemic mixture of the p53-Mdm2 protein-protein interaction inhibitor (−)-nutlin-3 (Item No. 18585) and its less active enantiomer (+)-nutlin-3 (Item No. 10009816). In vivo, (±)-nutlin-3 (200 mg/kg twice daily) reduces tumor volume in an SJSA-1 osteosarcoma mouse xenograft model.
[Uses]

(+/-)-Nutlin-3 is a small molecule MDM2 antagonist.
[Definition]

ChEBI: 4-[[4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazol-1-yl]-oxomethyl]-2-piperazinone is a stilbenoid.
[reaction suitability]

reagent type: ligand
[Biochem/physiol Actions]

Nutlin-3, an antagonist of a human homolog of murine double minute 2 (HDM2). It has the ability to inhibit the HDM2-directed degradation of p53. Nutlin-3 can also enhance the transcriptional activities of p73.
[storage]

Store at -20°C
[References]

1) Vassilev et al. (2004), In vivo activation of the p53 pathway by small-molecule antagonists of MDM2; Science, 303 844 2) Ghassemifar et al. (2012), MDM2 antagonism by nutlin-3 induces death in human medulloblastoma cells; Neurosci. Lett., 513 106 3) Manfe et al. (2012), MDM2 inhibitor nutlin-3 induces apoptosis and senescence in cutaneous T-cell lymphoma: role of p53; J. Invest. Dermatol., 132 1487 4) Kunkele et al. (2012), Pharmacological activation of the p53 pathway by nutlin-3 exerts anti-tumoral effects in medulloblastomas; Neuro. Oncol., 14 859
548472-68-0 suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Website: www.atkchemical.com
Company Name: Accela ChemBio Inc.
Tel: +1-858-6993322
Website: www.accelachem.com/
Company Name: BOC Sciences
Tel: +1-631-485-4226
Website: www.bocsci.com/
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: +8618523575427 , +8618523575427
Website: http://www.conier.com/
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695 , +8613203830695
Website: www.coreychem.com
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000 , +1-00000000000
Website: https://www.targetmol.com/
Company Name: Zhejiang J&C Biological Technology Co.,Limited
Tel: +1-2135480471 +1-2135480471 , +1-2135480471
Website: https://www.sarms4muscle.com
Company Name: Alfa Chemistry
Tel:
Website: www.alfa-chemistry.com/
Company Name: LEAP CHEM CO., LTD.
Tel: +86-852-30606658
Website: www.leapchem.com
Company Name: Wuhan Topule Biopharmaceutical Co., Ltd
Tel: +8618327326525 , +8618327326525
Website: topule.com/
Company Name: Jilin Chinese Academy of Sciences-yanshen Technology
Tel: +undefined18143011203 , +undefined18143011203
Website: www.chemextension.com/
Company Name: Aladdin Scientific
Tel:
Website: www.aladdinsci.com/
Company Name: Amadis Chemical Company Limited
Tel: 571-89925085
Website: http://www.amadischem.com
Company Name: Shanghai Bank Pharma Limited  Gold
Tel: 021-2221346380 021-54220652 17701603001
Website: http://m.approvedhomemanagement.com/ShowSupplierProductsList20106/0.htm
Company Name: Shanghai Boyle Chemical Co., Ltd.  
Tel:
Website: www.boylechem.com
Company Name: Chembest Research Laboratories Limited  
Tel: +86-21-20908456
Website: http://www.BioChemBest.com
Company Name: Goodee Pharma Co., Ltd.  
Tel: 0512-62956210
Website: www.goodeepharma.com
Company Name: Shanghai civi chemical technology co.,Ltd  
Tel: 86-21-34053660
Website: www.labgogo.com
Tags:548472-68-0 Related Product Information
675576-97-3 675576-98-4 331771-20-1 220127-57-1 341031-54-7 56-25-7 18637-00-8 119-54-0

This site uses cookies
This website uses cookies and similar technologies to store and retrieve information about your use of this website. This information helps us to provide, analyse and improve our services, which may include personalised content or advertising. We may share this information with Google and other third parties. This cookies are necessary for our website to work properly . By clicking "Continue" or continuing to browse our site you are agreeing to our and our partners use of cookies.
Accept