| Identification | Back Directory | [Name]
Benzoic acid, 4-[[(8-hydroxy-7-quinolinyl)phenylmethyl]amino]- | [CAS]
5335-97-7 | [Synonyms]
NSC-1011
3-BROMO-8-CHLOROPHENOL
Benzoic acid, 4-[[(8-hydroxy-7-quinolinyl)phenylmethyl]amino]- | [Molecular Formula]
C23H18N2O3 | [MDL Number]
MFCD30474843 | [MOL File]
5335-97-7.mol | [Molecular Weight]
370.41 |
| Hazard Information | Back Directory | [Uses]
NSC1011 is a potent Ras converting enzyme 1 endoprotease (Rce1) inhibitor with an IC50 value of 6.9 μM for HsRce1 (crystal structure of the human Rce1). NSC1011 induces mislocalizing EGFR-H-Ras, EGFR-N-Ras, and EGFR-K-Ras[1]. | [References]
[1] Mohammed I, et al. 8-Hydroxyquinoline-based inhibitors of the Rce1 protease disrupt Ras membrane localization in human cells. Bioorg Med Chem. 2016 Jan 15;24(2):160-78. DOI:10.1016/j.bmc.2015.11.043 |
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