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ChemicalBook--->CAS DataBase List--->525582-84-7

525582-84-7

525582-84-7 Structure

525582-84-7 Structure
IdentificationBack Directory
[Name]

SALOR-INT L368539-1EA
[CAS]

525582-84-7
[Synonyms]

VUAA1
SALOR-INT L368539-1EA
2-(4-ethyl-5-(3-pyridyl)(1,2,4-triazol-3-ylthio))-N-(4-ethylphenyl)acetamide
N-(4-ETHYLPHENYL)-2-((4-ET-5-(3-PYRIDINYL)-4H-1,2,4-TRIAZOL-3-YL)THIO)ACETAMIDE
N-(4-ethylphenyl)-2-((4-ethyl-5-(3-pyridinyl)-4H-1,2,4-triazol-3-yl)thio)acetamide
Acetamide, N-(4-ethylphenyl)-2-[[4-ethyl-5-(3-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-
[Molecular Formula]

C19H21N5OS
[MDL Number]

MFCD03194936
[MOL File]

525582-84-7.mol
[Molecular Weight]

367.47
Chemical PropertiesBack Directory
[density ]

1.25±0.1 g/cm3(Predicted)
[storage temp. ]

2-8°C
[solubility ]

DMSO: 20mg/mL, clear
[form ]

powder
[pka]

12.96±0.70(Predicted)
[color ]

white to beige
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319-H335
[Precautionary statements ]

P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard InformationBack Directory
[Uses]

VUAA1 is an insect odorant co-receptor (Orco) agonist. VUAA1 activates both heteromeric and homomeric Orco-containing channels. VUAA1 can disrupt the destructive behaviors of nuisance insects. VUAA1 can be used for insect olfactory research[1][2].
[Biochem/physiol Actions]

VUAA1 is an agonist of the highly conserved insect odorant receptor co-receptor ion channel Orco. VUAA1 is able to activate both heteromeric and homomeric Orco-containing channels, acting as an insect repellant by over-activating an insect′s olfactory senses causing a repellent effect.
[References]

[1] Corcoran JA, et al. Endogenous insensitivity to the Orco agonist VUAA1 reveals novel olfactory receptor complex properties in the specialist fly Mayetiola destructor. Sci Rep. 2018 Feb 22;8(1):3489. DOI:10.1038/s41598-018-21631-3
[2] Jones PL, et al. Functional agonism of insect odorant receptor ion channels. Proc Natl Acad Sci U S A. 2011 May 24;108(21):8821-5. DOI:10.1073/pnas.1102425108
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