| Identification | Back Directory | [Name]
SALOR-INT L368539-1EA | [CAS]
525582-84-7 | [Synonyms]
VUAA1
SALOR-INT L368539-1EA
2-(4-ethyl-5-(3-pyridyl)(1,2,4-triazol-3-ylthio))-N-(4-ethylphenyl)acetamide
N-(4-ETHYLPHENYL)-2-((4-ET-5-(3-PYRIDINYL)-4H-1,2,4-TRIAZOL-3-YL)THIO)ACETAMIDE
N-(4-ethylphenyl)-2-((4-ethyl-5-(3-pyridinyl)-4H-1,2,4-triazol-3-yl)thio)acetamide
Acetamide, N-(4-ethylphenyl)-2-[[4-ethyl-5-(3-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]- | [Molecular Formula]
C19H21N5OS | [MDL Number]
MFCD03194936 | [MOL File]
525582-84-7.mol | [Molecular Weight]
367.47 |
| Chemical Properties | Back Directory | [density ]
1.25±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 20mg/mL, clear | [form ]
powder | [pka]
12.96±0.70(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
VUAA1 is an insect odorant co-receptor (Orco) agonist. VUAA1 activates both heteromeric and homomeric Orco-containing channels. VUAA1 can disrupt the destructive behaviors of nuisance insects. VUAA1 can be used for insect olfactory research[1][2]. | [Biochem/physiol Actions]
VUAA1 is an agonist of the highly conserved insect odorant receptor co-receptor ion channel Orco. VUAA1 is able to activate both heteromeric and homomeric Orco-containing channels, acting as an insect repellant by over-activating an insect′s olfactory senses causing a repellent effect. | [References]
[1] Corcoran JA, et al. Endogenous insensitivity to the Orco agonist VUAA1 reveals novel olfactory receptor complex properties in the specialist fly Mayetiola destructor. Sci Rep. 2018 Feb 22;8(1):3489. DOI:10.1038/s41598-018-21631-3
[2] Jones PL, et al. Functional agonism of insect odorant receptor ion channels. Proc Natl Acad Sci U S A. 2011 May 24;108(21):8821-5. DOI:10.1073/pnas.1102425108 |
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