| Identification | Back Directory | [Name]
N-(2-{[4-nitro-2-(trifluoromethyl)phenyl]amino}ethyl)benzamide | [CAS]
524033-40-7 | [Synonyms]
NPBA
N-(2-{[4-nitro-2-(trifluoromethyl)phenyl]amino}ethyl)benzamide
Benzamide, N-[2-[[4-nitro-2-(trifluoromethyl)phenyl]amino]ethyl]- | [Molecular Formula]
C16H14F3N3O3 | [MOL File]
524033-40-7.mol | [Molecular Weight]
353.3 |
| Hazard Information | Back Directory | [Uses]
NPBA, a potassium K2P channel TASK-3 (KCNK9) agonist, is a tandem pore domain weak inward rectifying K+ channel (TWIK2) channel blocker. NPBA suppresses NLRP3 inflammasome activation in macrophages[1]. | [Biological Activity]
NPBA is a potent and selective agonist (activator) of potassium K2P channel TASK-3 (KCNK9). | [References]
[1] Fuyun Tian, et al. A Small-Molecule Compound Selectively Activates K2P Channel TASK-3 by Acting at Two Distant Clusters of Residues. Mol Pharmacol. 2019 Jul;96(1):26-35. DOI:10.1124/mol.118.115303
[2] Yuanxing Zhi, et al. A novel TWIK2 channel inhibitor binds at the bottom of the selectivity filter and protects against LPS-induced experimental endotoxemia in vivo. Biochem Pharmacol. 2023 Dec:218:115894. DOI:10.1016/j.bcp.2023.115894 |
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