| Identification | Back Directory | [Name]
Hydroxy-PEG-5-t-butyl ester | [CAS]
518044-32-1 | [Synonyms]
OH-PEG4-TBA
518044-32-1
HO-PEG4-COOtBu
PEG5-t-butly ester
HO-PEG4-CH2CH2COOTBU
OH-PEG4-CH2CH2COOtBu
Hydroxy-PEG4-(CH2)2-Boc
HO-PEG4 tert-Butyl Ester
tert-Butyl PEG4 propanoate
Hydroxy-PEG4-t-butly ester
Hydroxy-PEG-5-t-butyl ester
Hydroxy-dPEG4-t-butyl ester
t-Butyl 3-Hydroxy(PEG4)propoinate
PEG5-Carboxylic Acid tert-Butyl Ester
HYDROXY-PEG4-PROPANOIC ACID T-BUTYL ESTER
tert-Butyl 1-Hydroxy-3,6,9,12-tetraoxapentadecan-15-oate
1-Hydroxy-3,6,9,12-tetraoxapentadecan-15-oic Acid tert-Butyl Ester
4,7,10,13-Tetraoxapentadecanoic acid, 15-hydroxy-, 1,1-dimethylethyl ester
tert-butyl 3-(2-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)propanoate | [Molecular Formula]
C15H30O7 | [MDL Number]
MFCD11041117 | [MOL File]
518044-32-1.mol | [Molecular Weight]
322.394 |
| Chemical Properties | Back Directory | [Boiling point ]
406.8±35.0 °C(Predicted) | [density ]
1.04746 g/mL | [refractive index ]
n/D 1.4492 | [storage temp. ]
2-8°C | [solubility ]
Soluble in Water, DCM | [form ]
liquid | [pka]
14.36±0.10(Predicted) | [color ]
Colorless to Light yellow to Light orange |
| Hazard Information | Back Directory | [Description]
Hydroxy-PEG4-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Hydroxy-PEG4-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation. | [reaction suitability]
reagent type: cross-linking reagent |
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