| Identification | Back Directory | [Name]
ECHINOCYSTIC ACID | [CAS]
510-30-5 | [Synonyms]
Echinocystic
Albizziagenin
Echicystic acid
ECHINOCYSTIC ACID
ECHINOCYSTIC ACID(SH)
ECHINOCYSTIC ACID hplc
Echinocystic acid 510-30-5
ECHINOCYSTIC ACID WITH HPLC
ECHINOCYSTIC ACID USP/EP/BP
3β,16α-Dihydroxyolean-12-en-28-oic acid
Echinocystic acid, 98%, from Hedera Linn.
3-B,16-A-DIHYDROXYOLEAN-12-EN-28-OIC ACID
3β,16α-Dihydroxy-5α-oleana-12-ene-28-oic acid
3BETA,16ALPHA-DIHYDROXY-OLEAN-12-EN-28-OIC ACID
(3beta,16alpha)-3,16-dihydroxyolean-12-en-28-oic acid
(4aR,5R,6aR,6aS,6bR,8aR,10S,12aR,14bS)-5,10-dihydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid | [EINECS(EC#)]
208-112-3 | [Molecular Formula]
C30H48O4 | [MDL Number]
MFCD00017295 | [MOL File]
510-30-5.mol | [Molecular Weight]
472.7 |
| Chemical Properties | Back Directory | [Melting point ]
299-300°C | [Boiling point ]
585.0±50.0 °C(Predicted) | [density ]
1.14 | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMF:30.0(Max Conc. mg/mL);63.46(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.7(Max Conc. mM) | [form ]
powder | [pka]
4.43±0.70(Predicted) | [color ]
White | [LogP]
7.580 (est) |
| Hazard Information | Back Directory | [Description]
Echinocystic acid is a triterpene that has been found in G. sinensis and has diverse biological activities.1,2,3,4,5 It induces nuclear translocation of the glucocorticoid receptor (GR) and reduces TNF-α-induced NF-κB signaling in HEK293 cells overexpressing GFP-GR.1 Echinocystic acid (12.5, 25, and 50 μM) suppresses RANKL-induced NF-κB activation, ERK phosphorylation, and osteoclastogenesis in mouse bone marrow macrophages (BMMs).2 It induces neurite outgrowth in Neuro2A cells in a concentration-dependent manner, an effect that can be blocked by the JNK inhibitor SP 600125 (Item No. 10010466).3 In vivo, echinocystic acid (10 mg/kg per day) decreases escape latency in the Morris water maze and increases the length of neurite processes in the hippocampus of aged mice. Topical administration of echinocystic acid reduces expression of COX-2, inducible nitric oxide synthase (iNOS), TNF-α, and IL-1β and ear edema induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in a mouse model of dermatitis.4 Echinocystic acid also recovers reductions in femoral bone mineral density and trabecular thickness and number in a rat model of ovariectomy-induced osteoporosis.5 | [Uses]
Echinocystic Acid is a potential entry inhibitor for the HCV infection. | [Definition]
ChEBI: Echinocystic acid is a triterpenoid. |
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