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ChemicalBook--->CAS DataBase List--->501684-93-1

501684-93-1

501684-93-1 Structure

501684-93-1 Structure
IdentificationBack Directory
[Name]

NS 1738
[CAS]

501684-93-1
[Synonyms]

NS 1738
NSC 213859
1-(5-Chloro-2-hydroxy-phenyl)-3-(2-chloro-5-trifluoromethyl-phenyl)-urea
N-(5-Chloro-2-hydroxyphenyl)-N'-[2-chloro-5-(trifluoromethyl)phenyl]urea
Urea, N-(5-chloro-2-hydroxyphenyl)-N'-[2-chloro-5-(trifluoromethyl)phenyl]-
[Molecular Formula]

C14H9Cl2F3N2O2
[MDL Number]

MFCD11100189
[MOL File]

501684-93-1.mol
[Molecular Weight]

365.13
Chemical PropertiesBack Directory
[Boiling point ]

344.1±42.0 °C(Predicted)
[density ]

1.617±0.06 g/cm3(Predicted)
[storage temp. ]

Store at RT
[solubility ]

DMSO (Slightly), Methanol (Slightly)
[form ]

White crystalline solid.
[pka]

8.08±0.13(Predicted)
[color ]

Off-White to Light Grey
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H319
[Precautionary statements ]

P305+P351+P338
Hazard InformationBack Directory
[Description]

NS 1738 is a positive allosteric modulator of the α7-containing neuronal nicotinic acetylcholine receptors (nAChRs). When applied in the presence of ACh, NS 1738 increases the peak amplitude of the current flowing through α7-containing nAChRs (EC50 = 3.4 μM). NS 1738 displays no substantial activity for α4β2-, α3β3-, and α1-containing receptors. It is modestly brain-penetrant and counteracts (-)-scopolamine-induced deficit in acquisition of a water-maze learning task in rats. NS 1738 also improves performance in the rat social recognition test. NS 1738 is used to selectively evaluate the role of α7-containing nAChRs in signaling pathways.
[Uses]

NS 1738 is a selective a7 nAchR allosteric modulator.
[Biological Activity]

Selective positive allosteric modulator of α 7 nicotinic acetylcholine receptors. Exhibits no substantial activity for α 4 β 2, α 3 β 3 and α 1-containing receptors. Displays cognitive-enhancing properties in vivo .
[storage]

Store at RT
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