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ChemicalBook--->CAS DataBase List--->496793-75-0

496793-75-0

496793-75-0 Structure

496793-75-0 Structure
IdentificationBack Directory
[Name]

N-[3-(1H-benzimidazol-2-yl)-4-chlorophenyl]pyridine-3-carboxamide
[CAS]

496793-75-0
[Synonyms]

AZSMO23
AZSMO-23
AZSMO 23
N-[3-(1H-benzimidazol-2-yl)-4-chlorophenyl]pyridine-3-carboxamide
[Molecular Formula]

C19H13ClN4O
[MOL File]

496793-75-0.mol
[Molecular Weight]

348.79
Chemical PropertiesBack Directory
[density ]

1.426±0.06 g/cm3(Predicted)
[form ]

Solid
[pka]

10.94±0.10(Predicted)
[color ]

Off-white to light yellow
Hazard InformationBack Directory
[Description]

AZSMO-23 is an activator of the human ether-a-go-go-related gene (hERG)-encoded potassium channel (Kv11.1). It acts by blocking hKv4.3-hKChIP2.2, hCav3.2 and hKv1.5 and activating hCav1.2/β2/α2δ.
[Uses]

AZSMO-23 is a potent hERG K+ channel activator. AZSMO-23 activats WT hERG pre-pulse and tail current with EC50 values of 28.6, 11.2 μM, respectively. AZSMO-23 has the potential for the research of long QT syndrome[1].
[References]

[1] Mannikko R, et al. Pharmacological and electrophysiological characterization of AZSMO-23, an activator of the hERG K(+) channel. Br J Pharmacol. 2015 Jun;172(12):3112-25. DOI:10.1111/bph.13115
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