| Identification | Back Directory | [Name]
Eliglustat | [CAS]
491833-29-5 | [Synonyms]
CS-1540
Eliglustat
Genz 99067
Elli Gustast
Eliglustat(Genz-99067)
Eliglustat(GENZ 112638)
GENZ-99067; GENZ99067; GENZ 99067
GENZ-99067;GENZ99067;GENZ 99067;ELIGLUSTAT TARTRATE;GENZ-112638
N-[(1r,2r)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-hydroxy-3-pyrrolidin-1-ylpropan-2-yl]octanamide
N-[(1R,2R)-1-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-hydroxy-3-(1-
pyrrolidinyl)-2-propanyl]octanamide
N-[(1R,2R)-2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2-hydroxy-1-(1-pyrrolidinylmethyl)ethyl]-octanamide
Octanamide, N-[(1R,2R)-2-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-hydroxy-1-(1-pyrrolidinylmethyl)ethyl]- | [Molecular Formula]
C23H36N2O4 | [MDL Number]
MFCD19443735 | [MOL File]
491833-29-5.mol | [Molecular Weight]
404.54 |
| Chemical Properties | Back Directory | [Melting point ]
87-92°C | [Boiling point ]
615.5±55.0 °C(Predicted) | [density ]
1.123±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
13.45±0.20(Predicted) | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Uses]
Eliglustat is a specific and potent inhibitor of glucosylceramide synthase. | [Definition]
ChEBI: A carboxamide obtained by formal condensation of the carboxy group of octanoic acid with the primary amino group of (1R,2R)-2-amino-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-(pyrrolidin-1-yl)propan-1-ol. A ceramide glucosyltr
nsferase inhibitor used (as its tartrate salt) for treatment of Gaucher's disease. | [Biological Activity]
Eliglust at is a potent and selctive glucosylceramide synthase inhibitor approved for treatment of type 1 Gaucher disease. | [in vivo]
Mice that received drug prior to significant accumulation of substrate (10 weeks of age) showed reduced levels of glucosylceramide and number of Gaucher cells in the spleen, lung and liver when compared to age-matched control animals[1]. |
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