| Hazard Information | Back Directory | [Uses]
Cortistatin-8 (CST-8; PCFWKTCK), a neuropeptide, is a GHS-R1a antagonist by counteracting the response of ghrelin on gastric acid secretion. Cortistatin-8 can modulate GH release from somatotroph cells. Cortistatin-8 is a synthetic CST-analogue devoid of any binding affinity to SST-R but capable to bind the GHS-R1a. Cortistatin-8 can exert antagonistic effects on ghrelin actions either in vitro or in vivo in animals[1]. | [IC 50]
GHSR1a | [References]
[1] F Prodam, et al. Cortistatin-8, a synthetic cortistatin-derived ghrelin receptor ligand, does not modify the endocrine responses to acylated ghrelin or hexarelin in humans. Neuropeptides. 2008 Feb;42(1):89-93. DOI:10.1016/j.npep.2007.09.006 |
|
| Company Name: |
|
| Tel: |
821-50328103-801 18930552037 |
| Website: |
http://m.approvedhomemanagement.com/ShowSupplierProductsList13285/0.htm |
|