| Identification | Back Directory | [Name]
Oroxylin | [CAS]
480-11-5 | [Synonyms]
Oroxylin
OLOXYLINA
oxoxylin A
Oroxylia A
6-Methoxybaicalein
Baicalein 6-methyl ether
5,7-Dihydroxy-6-methoxyflavone
5,7-Dihydroxy-6-methoxy-2-phenyl-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 5,7-dihydroxy-6-methoxy-2-phenyl- | [Molecular Formula]
C16H12O5 | [MDL Number]
MFCD02259441 | [MOL File]
480-11-5.mol | [Molecular Weight]
284.26 |
| Chemical Properties | Back Directory | [Melting point ]
195-197℃ | [Boiling point ]
346.76°C (rough estimate) | [density ]
1.420 | [refractive index ]
1.6200 (estimate) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:4): 0.20 mg/ml | [form ]
powder | [pka]
6.48±0.40(Predicted) | [color ]
Yellow | [InChI]
InChI=1S/C16H12O5/c1-20-16-11(18)8-13-14(15(16)19)10(17)7-12(21-13)9-5-3-2-4-6-9/h2-8,18-19H,1H3 | [InChIKey]
LKOJGSWUMISDOF-UHFFFAOYSA-N | [SMILES]
C1(C2=CC=CC=C2)OC2=CC(O)=C(OC)C(O)=C2C(=O)C=1 |
| Hazard Information | Back Directory | [Uses]
food and beverages | [Definition]
ChEBI: A dihydroxy- and monomethoxy-flavone in which the hydroxy groups are positioned at C-5 and C-7 and the methoxy group is at C-6. | [Biological Activity]
Oroxylin A is a flavonoid isolated from Scutellaria baicalensiswhich is one of the most important medicinal herbs in traditional Korean/Chinese/Japanese medicine. The amelioration of Abeta(25-35) peptide-induced memory impairment by oroxylin A is believed to be mediated via the GABAergic neurotransmitter system after a single administrationor by reductions in Abeta(25-35) peptide-induced astrocyte and microglia activationsiNOS expressionlipid peroxidationand increased cholinergic neurotransmission after subchronic administration. |
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