| Identification | Back Directory | [Name]
CARDIN | [CAS]
477-32-7 | [Synonyms]
Selva
CARDIN
cardine
carduben
VISNADIN
visnadine
carduben-s
CARDIN USP/EP/BP
Visnadine >=95% (LC/MS-ELSD)
2h,8h-benzo(1,2-b:3,4-b’)dipyran-2-one-acetate
3-(alpha-methylbutyryloxy)-4-acetoxy-3,4-dihydroseseline
(alpha-methylbutyryloxy)-3’-acetoxy-4’-dihydro-3’,4’-seselin
2-methyl-,9-esterwith9,10-dihydro-9,10-dihydroxy-8,8-dimethyl-butyricaci
(9R)-9,10-Dihydro-9α,10α-dihydroxy-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-2-one 10-acetate 9-[(R)-α-methylbutyrate]
(R)-2-Methylbutyric acid (9R,10α)-10-acetyloxy-9,10-dihydro-8,8-dimethyl-2-oxo-2H,8H-benzo[1,2-b:3,4-b']dipyran-9-yl ester
Butanoic acid,2-methyl-,(9R,10R)-10-(acetyloxy)-9,10-dihydro-8,8-dimethyl-2-oxo-2H,8H-benzo[1,2-b:3,4-b']dipyran-9-ylester, (2R)- | [EINECS(EC#)]
207-515-1 | [Molecular Formula]
C21H24O7 | [MDL Number]
MFCD00075897 | [MOL File]
477-32-7.mol | [Molecular Weight]
388.41 |
| Chemical Properties | Back Directory | [Melting point ]
85-88° | [alpha ]
D20 +9.2° (alc); D30 +42.5° (c = 2 in dioxane) | [Boiling point ]
434.13°C (rough estimate) | [density ]
1.2086 (rough estimate) | [refractive index ]
1.5300 (estimate) | [storage temp. ]
?20°C | [form ]
solid | [CAS DataBase Reference]
477-32-7 |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,N | [Risk Statements ]
22-50 | [Safety Statements ]
61 | [RIDADR ]
UN 3077 9 / PGIII | [WGK Germany ]
3 | [Toxicity]
LD50 in mice (mg/kg): 2240 orally; >370 s.c. (Erbring) |
| Hazard Information | Back Directory | [Originator]
Vibeline ,Bellon ,France,1960 | [Uses]
Visnadine is used as a coumarin scaffold for anti-inflammatory drug development, melanin biosynthetic inhibitory activity, anticellulite efficacy in female patient with cellulite blemish affected by fat accumulation or new anticellulite treatment. | [Definition]
ChEBI: Visnadin is a member of coumarins. | [Manufacturing Process]
Ammi visnaga is a plant of the Umbelliferae family, which has been known and
used for its therapeutic properties by the peoples of the Mediterranean basin
since time immemorial.
Visnadine may be extracted from the umbels of Ammi visnaga by an organic
solvent having a boiling point less than 110°C. The resulting solution is
concentrated first by heating in a water bath and then is allowed to stand
some time at a temperature of about 20°C and if necessary is treated for
separation of gummy constituents therefrom, after which the solution is
concentrated under reduced pressure. Finally, the crude product is crystallized
and separated by retaining it on a filter.
This crude product may then, according to the process, be purified by mixing
it with petroleum ether and allowing it to stand at ordinary temperature, then
filtering it to obtain the pure visnadine. | [Therapeutic Function]
Coronary vasodilator, Antiarrhythmic |
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