| Identification | Back Directory | [Name]
RUSCOGENIN | [CAS]
472-11-7 | [Synonyms]
FlebopoM
HeModren
472-11-7
RUSCOGENIN
RUSCOGENINE
Rectolander
Ruscorectal
RUSCOGENIN(P)
Ruscogenins CRS
RUSCOGENIN USP/EP/BP
25D-Spirost-5-ene-1β,3β-diol
(25R)-Spirost-5-ene-1β,3β-diol
(1B,3B,25R)-SPIROST-5-ENE-1,3-DIOL
(1β,3β,25R)-Spirost-5-ene-1,3-diol
Spirost-5-ene-1,3-diol, (1β,3β,25R)-
Ruscogenin, froM Ophiopogon japonicus
(25R)-spirost-5-ene-1-beta,3-beta-diol
(1beta,3beta,25R)-Spirost-5-ene-1,3-diol
Spirost-5-ene-1,3-diol, (1.beta.,3.beta.,25R)-
Ruscogenin, 98%, from Ophiopogon japonicus (Thunb.) Ker Gawl. | [EINECS(EC#)]
207-447-2 | [Molecular Formula]
C27H42O4 | [MDL Number]
MFCD00210550 | [MOL File]
472-11-7.mol | [Molecular Weight]
430.62 |
| Chemical Properties | Back Directory | [Melting point ]
198-202℃ | [Boiling point ]
563.1±50.0 °C(Predicted) | [density ]
1.18 | [storage temp. ]
-20°C Freezer | [solubility ]
DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
14.56±0.70(Predicted) | [color ]
White |
| Hazard Information | Back Directory | [Chemical Properties]
White powder | [Uses]
A major steroidal sapogenin from Radix ophiopogon japonicus with robust anti-inflammatory and anti-thrombotic activities. Studies suggest that it inhibits adhesion of leukocytes to a human umbilical v
ein endothelial cell line (ECV304) injured by tumor necrosis factor-α (TNF-α) in a concentration-dependent manner. | [Definition]
ChEBI: Ruscogenin is a triterpenoid. | [Biological Activity]
Ruscogenin is a well-known compound for down-regulating nuclear factor kappa B (NF-KB)intercellular adhesion molecule-1 (ICAM-1)tissue factor (TF)inducible NO synthase (iNOS)and modulating inflammatory pathways. It displays anti-inflammatory properties by inhibiting lipopolysaccharide (LPS)-induced acute lung injury (ALI)and improving diabetic nephropathy in in vivo studies. Ruscogenin also exerts neuroprotective properties and protects the brain against ischemic injury in mouse model. It elicits anti-tumor properties by inducing ferroptosis in pancreatic cancer cells in both in vitro and in vivo studies. | [target]
PGE | TNF-α | NF-kB | p65 | NO | NOS | COX | ERK | JNK | Akt | p38MAPK | PKA | cAMP | IL Receptor |
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