| Identification | Back Directory | [Name]
UNCARINE D | [CAS]
4697-68-1 | [Synonyms]
Nsc113094
Uncarin D
UNCARINE D
SPECIOPHYLLINE
Speciophylline (Uncarine D)
(3β,7S,20α)-19α-Methyl-2-oxoformosanan-16-carboxylic acid methyl ester
Spiro[3H-indole-3,6'(4'aH)-[1H]pyrano[3,4-f]indolizine]-4'-carboxylic acid, 1,2,5',5'a,7',8',10',10'a-octahydro-1'-methyl-2-oxo-, methyl ester, (1'S,3S,4'aS,5'aR,10'aS)- | [Molecular Formula]
C21H24N2O4 | [MDL Number]
MFCD03788765 | [MOL File]
4697-68-1.mol | [Molecular Weight]
368.43 |
| Hazard Information | Back Directory | [Description]
One of the alkaloids isolated from the leaves of Mitragyna speciosa, the structure
of the base has been determined from the NMR spectrum which demonstrates
that the alkaloid has a cis DIE ring junction and a conformation such that the
oxindole ring deshields the ester methoxyl group. | [Uses]
Uncarine D is a compound extracted from Uncaria tomentosa leaves. The compounds extracted from these leaves have exhibited immunomodulating, antiinflammatory and anti-cancer activity, attributed to the presence of tetra/pentacyclic oxindole alkaloids. | [Definition]
ChEBI: Uncarine D is a member of indolizines. | [References]
Beckett et al., Sci. Pharm., Froc., 25th (1965) |
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