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ChemicalBook--->CAS DataBase List--->459147-39-8

459147-39-8

459147-39-8 Structure

459147-39-8 Structure
IdentificationBack Directory
[Name]

2-butylsulfinyl-4-phenyl-6-thiophen-2-ylthieno[5,4-b]pyridin-3-amine
[CAS]

459147-39-8
[Synonyms]

CS-1608
SW033291
SW033291(SW-033291)
SW033291 >=98% (HPLC)
SW033291;SW-033291;SW033291;SW 033291
2-butylsulfinyl-4-phenyl-6-thiophen-2-ylthieno[5,4-b]pyridin-3-amine
2-(Butylsulfinyl)-4-phenyl-6-(2-thienyl)thieno[2,3-b]pyridin-3-amine
4-phenyl-6-(thiophen-2-yl)-2-thioxo-1,2- dihydropyridine-3-carbonitrile
Thieno[2,3-b]pyridin-3-amine, 2-(butylsulfinyl)-4-phenyl-6-(2-thienyl)-
2-(butylsulfinyl)-4-phenyl-6-(thiophen-2-yl)thieno[2,3-b]pyridin-3-amine
2-(Butane-1-sulfinyl)-4-phenyl-6-thiophen-2-yl-thieno[2,3-b]pyridin-3-ylamine
2-(Butane-1-sulfinyl)-4-phenyl-6-thiophen-2-yl-thieno[2,3-b]pyridin-3-ylamine (SW033291)
[Molecular Formula]

C21H20N2OS3
[MDL Number]

MFCD02973087
[MOL File]

459147-39-8.mol
[Molecular Weight]

412.59
Chemical PropertiesBack Directory
[Melting point ]

>99°C (Dec)
[storage temp. ]

2-8°C
[solubility ]

DMSO (Slightly), Methanol (Slightly)
[form ]

powder
[color ]

light yellow to yellow-green
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319-H335
[Precautionary statements ]

P305+P351+P338
Hazard InformationBack Directory
[Uses]

SW033291 is an inhibitor which maintains the ability to promote tissue regeneration through inhibition of prostaglandin-degrading enzyme 15-PGDH.
[Biological Activity]

SW033291 is an inhibitor of the prostaglandin-degrading enzyme 15-PGDH. PGE2 is known to promote hematopoiesis and to promote reeneration by causing stem cells to proliferate. 15-PGDH degrades prostaglandin PGE2 and is a negative regulator of tissue regeneration and repair. SW033291 inhibition of 15-PGDH doubled levels of PGE2 and doubled rates of colon and liver tissue regeneration. Mice given SW033291 after receiving a bone marrow transplant had a two- to threefold increase in the number of donor cells th at homed to the their bone marrow.
[storage]

Store at -20°C
Spectrum DetailBack Directory
[Spectrum Detail]

2-butylsulfinyl-4-phenyl-6-thiophen-2-ylthieno[5,4-b]pyridin-3-amine(459147-39-8)1HNMR
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