| Identification | Back Directory | [Name]
kobe-2602 | [CAS]
454453-49-7 | [Synonyms]
CS-1280
kobe2602
kobe-2602
kobe 2602
kobe2602, >96%
Kobe 2602, >=98%
KOBE 2602; KOBE-2602
2-[2,6-Dinitro-4-(trifluoroMethyl)phenyl]-N-(4-fluorophenyl)hydrazinecarbothioaMide
Hydrazinecarbothioamide, 2-[2,6-dinitro-4-(trifluoromethyl)phenyl]-N-(4-fluorophenyl)-
kobe-2602 2-[2,6-Dinitro-4-(trifluoromethyl)phenyl]-N-(4-fluorophenyl)hydrazinecarbothioamide | [Molecular Formula]
C14H9F4N5O4S | [MDL Number]
MFCD04109605 | [MOL File]
454453-49-7.mol | [Molecular Weight]
419.31 |
| Chemical Properties | Back Directory | [Boiling point ]
450.8±55.0 °C(Predicted) | [density ]
1.691±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
insoluble in H2O; ≥17 mg/mL in DMSO; ≥17.53 mg/mL in EtOH with ultrasonic | [form ]
solid | [pka]
9.35±0.70(Predicted) | [color ]
Light yellow to brown |
| Hazard Information | Back Directory | [Uses]
Kobe 2602 is used in the preparation of pyrazolidine or pyrazole compounds which exhibit mild antimicrobial effects against various strains of bacteria.
| [Biological Activity]
kobe2602 is a small-molecule inhibitor of ras with ki value of 149 μm [1].kobe2602 is a compound screened out by a computer-assisted search of about 160,000 compounds. it dose-dependently inhibited the binding of h-rasg12v to c-raf-1 in nih 3t3 cells with a rough ic50 value of 10 μm. 20 μm of kobe2602 effectively suppressed the phosphorylation of down-stream kinases of raf, including mek and erk. besides that, in nih 3t3 cells transfected with h-rasg12v, kobe2602 inhibited the colony formation with ic50 value of 1.4 μm. kobe2602 also showed effect on other cancer cells carrying activated ras oncogenes, such as panc-1(k-rasg12v), ht1080 (n-rasq61l) and hct116 (h-rasg13d). moreover, in mice bearing sw480 xenografts, administration of kobe2602 resulted in 40-50% inhibition of the tumor growth at dose of 80 mg/kg [1]. | [in vivo]
Kobe2602 (80 mg/kg; p.o.; five consecutive days per week; for 17 days) exhibits antitumor activity on a xenograft of human colon carcinoma SW480 cells carrying the K-RasG12V gene[1].
| Animal Model: | Female athymic nude mice (6-8 wk old), with SW480 cells xenograft[1] | | Dosage: | 80 mg/kg | | Administration: | Oral administration, five consecutive days per week, for 17 days | | Result: | Caused inhibition of the tumor growth. |
| [References]
[1] shima f, yoshikawa y, ye m, et al. in silico discovery of small-molecule ras inhibitors that display antitumor activity by blocking the ras–effector interaction. proceedings of the national academy of sciences, 2013, 110(20): 8182-8187. |
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