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ChemicalBook--->CAS DataBase List--->445007-59-0

445007-59-0

445007-59-0 Structure

445007-59-0 Structure
IdentificationBack Directory
[Name]

N-(2,5-dimethylphenyl)-N'-(3-methylphenyl)urea
[CAS]

445007-59-0
[Synonyms]

N-(2,5-dimethylphenyl)-N'-(3-methylphenyl)urea
[Molecular Formula]

C16H18N2O
[MOL File]

445007-59-0.mol
[Molecular Weight]

254.327
Hazard InformationBack Directory
[Description]

AK963, also known as 40708899, is a potent PAK1 (p21-activated kinase 1) inhibitor, which suppresses the proliferation of human gastric cancer cells significantly by downregulation of PAK1-NFκB-CyclinB1 pathway.
[Uses]

AK963/40708899 is a potent PAK1 inhibitor. AK963/40708899 suppresses the proliferation of human gastric cancer cells by downregulation of PAK1-NF-κB-cyclinB1 pathway. AK963/40708899 induces cell cycle arrest at G2 phase and reduces the migration and invasion. AK963/40708899 inhibits the formation of filopodia and promots cell adhesion which in turn inhibits invasive potential of gastric cells by negatively regulating PAK1-LIMKl-cofilin and PAK1-ERK-FAK pathways[1].
[IC 50]

PAK1
[References]

[1] Ying Zhou, et al. Targeting PAK1 with the Small Molecule Drug AK963/40708899 Suppresses Gastric Cancer Cell Proliferation and Invasion by Downregulation of PAK1 Activity and PAK1-Related Signaling Pathways. Anat Rec (Hoboken). 2019 Sep;302(9):1571-1579. DOI:10.1002/ar.24095
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