| Identification | Back Directory | [Name]
CK-636 | [CAS]
442632-72-6 | [Synonyms]
CK-636
CK-0944636
CK-636, >=98%
N-[2-(2-Methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide
N-[2-(2-Methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide CK636
CK-636 N-[2-(2-Methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide | [EINECS(EC#)]
200-256-5 | [Molecular Formula]
C16H16N2OS | [MDL Number]
MFCD03036245 | [MOL File]
442632-72-6.mol | [Molecular Weight]
284.376 |
| Questions And Answer | Back Directory | [Description]
CK-636 is an Arp2/3 complex inhibitor with IC50 of 4 μM, 24 μM and 32 μM for inhibition of actin polymerization induced by human, fission yeast and bovine Arp2/3 complex, respectively. | [In vitro]
CK-636 inhibits actin polymerization mediated by Arp2/3 complex in live cells, and reduces the formation of actin filament comet tails by Listeria in infected SKOV3 cells. CK-636 inhibits lamellipodia formation at the leading edges of migrating T cells, and causes reduced velocity. In addition, a substantial fraction of CK-636-treated T cells on zigzag patterns with an acute turning angle are trapped near the interfaces formed by the turning points of zigzag patterns.
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| Hazard Information | Back Directory | [Uses]
CK-636 is a small molecule that inhibits Actin-related protein 2/3 (Arp2/3) (1). Arp2/3 is a 7 subunits protein complex that regulates actin cytoskeleton (2). CK-636 interacts with Arp2/3 and prevents actin polymerization. | [Biological Activity]
CK-636 binds between Arp2 and Arp3where it appears to block movement of Arp2 and Arp3 into their active conformation. CK-636 inserts into the hydrophobic core of Arp3 and alters its conformation. Both classes of compounds inhibit formation of actin filament comet tails by Listeria and podosomes by monocytes. | [storage]
Store at -20° C |
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| Company Name: |
China Langchem Inc.
|
| Tel: |
0086-21-58956006 |
| Website: |
m.approvedhomemanagement.com/ShowSupplierProductsList19141/0.htm |
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
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