Identification | Back Directory | [Name]
4E2RCat | [CAS]
432499-63-3 | [Synonyms]
4E2RCat Eukaryotic Initiation Factor Benzoic acid, 2-chloro-5-[5-[[4-oxo-3-(phenylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]- | [Molecular Formula]
C22H14ClNO4S2 | [MDL Number]
MFCD03706106 | [MOL File]
432499-63-3.mol | [Molecular Weight]
455.93 |
Chemical Properties | Back Directory | [Boiling point ]
659.0±65.0 °C(Predicted) | [density ]
1.56±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 15.5 mg/mL (34.00 mM) | [form ]
Solid | [pka]
2.72±0.25(Predicted) | [color ]
Light yellow to yellow |
Hazard Information | Back Directory | [Uses]
4E2RCat is an inhibitor of eIF4E-eIF4G interaction with an IC50 of 13.5 μM. | [in vivo]
4E2RCat inhibits protein synthesis in vivo and it is not a consequence of increased cell death[1]. | [IC 50]
eIF4 | [References]
[1] Cencic R, et al. Blocking eIF4E-eIF4G interaction as a strategy to impair coronavirus replication. J Virol. 2011 Jul;85(13):6381-9. DOI:10.1128/JVI.00078-11 |
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