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ChemicalBook--->CAS DataBase List--->432499-63-3

432499-63-3

432499-63-3 Structure

432499-63-3 Structure
IdentificationBack Directory
[Name]

4E2RCat
[CAS]

432499-63-3
[Synonyms]

4E2RCat
Eukaryotic Initiation Factor
Benzoic acid, 2-chloro-5-[5-[[4-oxo-3-(phenylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]-
[Molecular Formula]

C22H14ClNO4S2
[MDL Number]

MFCD03706106
[MOL File]

432499-63-3.mol
[Molecular Weight]

455.93
Chemical PropertiesBack Directory
[Boiling point ]

659.0±65.0 °C(Predicted)
[density ]

1.56±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 15.5 mg/mL (34.00 mM)
[form ]

Solid
[pka]

2.72±0.25(Predicted)
[color ]

Light yellow to yellow
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P280-P301+P312-P302+P352-P305+P351+P338
Hazard InformationBack Directory
[Uses]

4E2RCat is an inhibitor of eIF4E-eIF4G interaction with an IC50 of 13.5 μM.
[in vivo]

4E2RCat inhibits protein synthesis in vivo and it is not a consequence of increased cell death[1].

[IC 50]

eIF4
[References]

[1] Cencic R, et al. Blocking eIF4E-eIF4G interaction as a strategy to impair coronavirus replication. J Virol. 2011 Jul;85(13):6381-9. DOI:10.1128/JVI.00078-11
Spectrum DetailBack Directory
[Spectrum Detail]

4E2RCat(432499-63-3)1HNMR
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