| Identification | Back Directory | [Name]
4-Fluoro-n-(3-fluoro-4-methylphenyl)-3-([(4-methoxyphenyl)methyl]sulfamoyl)benzamide | [CAS]
422546-87-0 | [Synonyms]
NFAT Inhibitor-2
4-Fluoro-n-(3-fluoro-4-methylphenyl)-3-([(4-methoxyphenyl)methyl]sulfamoyl)benzamide
Benzamide, 4-fluoro-N-(3-fluoro-4-methylphenyl)-3-[[[(4-methoxyphenyl)methyl]amino]sulfonyl]-
cardiovascular,calcineurin,4fluoroN(3fluoro4methylphenyl)3{[(4methoxyphenyl)methyl]sulfamoyl}benzamide,inhibit,Inhibitor,NFAT signalling,4 fluoro N (3 fluoro 4 methylphenyl) 3 {[(4 methoxyphenyl)methyl]sulfamoyl}benzamide,serine/threonine protein phosphatase,NFAT Inhibitor2,inflammatory,NFAT Inhibitor-2,NFAT Inhibitor 2 | [Molecular Formula]
C22H20F2N2O4S | [MDL Number]
MFCD15094766 | [MOL File]
422546-87-0.mol | [Molecular Weight]
446.47 |
| Hazard Information | Back Directory | [Uses]
NFAT Inhibitor-2 is a potent inhibitor of calcineurin NFAT signalling. Calcineurin is a serine/threonine protein phosphatase regulated by Ca2+ and calmodulin. NFAT Inhibitor-2 has the potential for the research of inflammatory disease, an autoimmune disorder, a cardiovascular disease, a neurodegenerative disease, a disease occurring with uncontrolled cell proliferation and/or differentiation, an angiogenesis-related disease, an allergy, anaphylaxis and alopecia (extracted from patent WO2016207212A1, compound 17)[1]. | [References]
[1] Mercè PéREZ RIBA, et al. Therapeutic uses of non-peptide inhibitors of the calcineurin - nfat signalling pathway. Patent WO2016207212A1. |
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A2B Chem LLC
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010 |
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www.a2bchem.com |
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