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ChemicalBook--->CAS DataBase List--->400797-24-2

400797-24-2

400797-24-2 Structure

400797-24-2 Structure
IdentificationBack Directory
[Name]

JNJ 10329670
[CAS]

400797-24-2
[Synonyms]

JNJ 10329670
JNJ10329670,JNJ 10329670
2H-Benzimidazol-2-one, 5-chloro-1,3-dihydro-1-methyl-3-[1-[3-[4,5,6,7-tetrahydro-5-(methylsulfonyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazolo[4,3-c]pyridin-1-yl]propyl]-4-piperidinyl]-
[Molecular Formula]

C30H34ClF3N6O3S
[MOL File]

400797-24-2.mol
[Molecular Weight]

651.14
Chemical PropertiesBack Directory
[Boiling point ]

752.0±70.0 °C(Predicted)
[density ]

1.47±0.1 g/cm3(Predicted)
[pka]

8.76±0.10(Predicted)
Hazard InformationBack Directory
[Uses]

JNJ 10329670 is a potent and selective noncovalent cathepsin S inhibitor with a Ki value of 34 nM for human cathepsin S. JNJ 10329670 blocks invariant chain proteolysis in B cells and dendritic cells, as well as antigen-induced T cell proliferation[1].
[IC 50]

cathepsin S: 34 nM (Ki)
[References]

[1] Thurmond RL, et, al. Identification of a potent and selective noncovalent cathepsin S inhibitor. J Pharmacol Exp Ther. 2004 Jan;308(1):268-76. DOI:10.1124/jpet.103.056879
400797-24-2 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website: www.targetmol.com/
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website:
Company Name: Hefei fuya biotechnology co. LTD  
Tel: 18096409024
Website: http://www.purerechem.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
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