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ChemicalBook--->CAS DataBase List--->380572-02-1

380572-02-1

380572-02-1 Structure

380572-02-1 Structure
IdentificationBack Directory
[Name]

(E)-6-(4-hydroxy-3-methoxybenzylidene)-5-imino-2-(trifluoromethyl)-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7(6H)-one
[CAS]

380572-02-1
[Synonyms]

(E)-6-(4-hydroxy-3-methoxybenzylidene)-5-imino-2-(trifluoromethyl)-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7(6H)-one
[Molecular Formula]

C14H9F3N4O3S
[MOL File]

380572-02-1.mol
[Molecular Weight]

370.31
Chemical PropertiesBack Directory
[Boiling point ]

428.5±55.0 °C(Predicted)
[density ]

1.69±0.1 g/cm3(Predicted)
[form ]

Solid
[pka]

9.28±0.35(Predicted)
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Description]

SRPIN-803 is a selective dual inhibitor of SRPK1 and CK2.
[Uses]

SRPIN803 is a potent CK2 and SRPK1 dual inhibitor, with IC50s of 203 nM and 2.4 μM, respectively. SRPIN803 exhibits antiangiogenic activity. SRPIN803 can be used for the research of age-related macular degeneration[1][2][3].
[in vivo]

SRPIN803 (topical administration of eye ointment) significantly inhibits choroidal neovascularization in a mouse model of age-related macular degeneration[2].
SRPIN803 (100 μM; 72 h) inhibit zebrafish angiogenesis[2].
SRPIN803 (4.6 nL of 10 μM; microinjection; 72 h) block angiogenesis in the developing embryo at the one-cell stage of zebrafish[2].

[IC 50]

CK2: 203 nM (IC50); SRPK1: 2.4 μM (IC50)
[References]

[1] Leonidis G, et, al. Synthesis and Biological Evaluation of a c(RGDyK) Peptide Conjugate of SRPIN803. ACS Omega. 2021 Oct 14;6(42):28379-28393. DOI:10.1021/acsomega.1c04576
[2] Vedove AD, et, al. A novel class of selective CK2 inhibitors targeting its open hinge conformation. Eur J Med Chem. 2020 Jun 1;195:112267. DOI:10.1016/j.ejmech.2020.112267
[3] Morooka S, et, al. Identification of a Dual Inhibitor of SRPK1 and CK2 That Attenuates Pathological Angiogenesis of Macular Degeneration in Mice. DOI:10.1124/mol.114.097345
380572-02-1 suppliers list
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