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ChemicalBook--->CAS DataBase List--->37795-69-0

37795-69-0

37795-69-0 Structure

37795-69-0 Structure
IdentificationBack Directory
[Name]

2,3-DIHYDRO-ISOXAZOLO[3,2B]QUINAZOLIN-9-ONE
[CAS]

37795-69-0
[Synonyms]

W-2429
NSC294836
2,3-DIHYDRO-ISOXAZOLO[3,2B]QUINAZOLIN-9-ONE
2,3-Dihydro-9H-isoxazolo[3,2-b]quinazolin-9-one
9H-Isoxazolo[3,2-b]quinazolin-9-one, 2,3-dihydro-
[Molecular Formula]

C10H8N2O2
[MDL Number]

MFCD00869447
[MOL File]

37795-69-0.mol
[Molecular Weight]

188.18
Chemical PropertiesBack Directory
[Boiling point ]

323.18°C (rough estimate)
[density ]

1.2577 (rough estimate)
[refractive index ]

1.5910 (estimate)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
Hazard InformationBack Directory
[Uses]

W-2429 (NSC294836) is considerably more effective than acetylsalicylic acid in inhibiting carrageenan-induced edema and in reducing brewer's yeast-induced fever in rats[2].
[in vivo]

W-2429 is a non-narcotic analgesic agent. Treatment with W-2429 is well tolerated by rats as well as dogs. In the dog, the only signs of toxicity observed are decreased appetite and salivation at 100 mg/kg/day W-2429. No other significant evidence of physical, chemical, gross or histopathologic change is observed[1].

[storage]

Store at -20°C
[References]

[1] Banerjee BN, et al. Toxicological investigation of 2,3-dihydro-9H-isoxazolo[3,2-b]quinazolin-9-one (W-2429). Acuteand subacute toxicity in mice, rats and dogs. Arzneimittelforschung. 1977;27(4):793-801. PMID:301393
[2] Reisner DB, Ludwig BJ, Simon E, Dejneka T, Sofia RD. 2,3-Dihydro-9H-isoxazolo[3,2-b]quinazolin-9-ones and 3,4-dihydro-(1,2)-oxazino [3,2-b]quinazolin-10(2H)-ones. Arzneimittelforschung. 1977;27(4):766-770. PMID:301391
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