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ChemicalBook--->CAS DataBase List--->37318-06-2

37318-06-2

37318-06-2 Structure

37318-06-2 Structure
IdentificationBack Directory
[Name]

elaiophylin
[CAS]

37318-06-2
[Synonyms]

EfoMycin E
EfoMycine E
GopalaMicin
elaiophylin
Azalomycin B
255-E, 5001B, 56-62, 846 I, SNA 4606-3, AzaloMycin B, GopalaMicin, SalboMycin
[Molecular Formula]

C54H88O18
[MOL File]

37318-06-2.mol
[Molecular Weight]

1025.27
Chemical PropertiesBack Directory
[Melting point ]

179-182℃
[Boiling point ]

1080.5±65.0 °C(Predicted)
[density ]

1.25
[storage temp. ]

-20°C Freezer
[solubility ]

DMSO (Slightly), Methanol (Slightly)
[form ]

White to off-white solid.
[pka]

12.18±0.70(Predicted)
[color ]

White to Off-White
Hazard InformationBack Directory
[Uses]

Elaiophylin is a highly characteristic metabolite produced by Streptomyces hygroscopicus. Elaiophylin inhibits testosterone 5-reductase. Elaiophylin is synergistic with its co-metabolite, rapamycin, as an antifungal. Elaiophylin also has anthelmintic and immunosuppressive activity and inhibits NO synthesis. Elaiophylin displays broad, albeit weak, biological activity against bacteria, nematodes, protozoa and mammalian tumor cells.
[Uses]

Elaiophylin is a macrodiolide antibiotic that can be isolated from various strains of Streptomyces. It displays in vitro anti-protozoal activity against both Plasmodium and Trypanosoma (IC50s = 370 and 460 ng/ml, respectively) and cytotoxicity against human fetal lung fibroblast MRC-5 cells (IC50 = 870 ng/ml). Elaiophylin alone has no activity against Candida, although it enhances the anti-fungal activity of rapamycin . Elaiophylin also forms stable, long-lasting ion channels in bilayer membranes that are selective for cations.
[Uses]

Elaiophyllin is a highly characteristic metabolite produced by Streptomyces hygroscopicus. Elaiophylin inhibits testosterone 5-reductase. Elaiophylin is synergistic with its co-metabolite, rapamycin, as an antifungal. Elaiophylin also has anthelminthic and immunosuppressive activity and inhibits NO synthesis. Elaiophylin displays broad, albeit weak, biological activity against bacteria, nematodes, protozoa and mammalian tumour cells.
[Definition]

ChEBI: A macrolide that is isolated from several bacteria including Streptomyces violaceoniger and other soil actinomycetes.
[Biological Activity]

Macrolide antibiotic inhibiting testosterone 5-reductase and plasma-proton ATPase (P-ATPase). Shows antifungal, antiprotozoal, antitumor, antihelmintic and immunosuppressive activity.
[storage]

Store at -20°C
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