| Identification | Back Directory | [Name]
ethyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate | [CAS]
37178-37-3 | [Synonyms]
TV-1203
L-Dopa-Et
O-Ethyl-DOPA
L-DOPA Ethyl Ester
Levodopa ethyl ester
L-Dopa ethyl ester >=98% (HPLC)
3-Hydroxy-L-tyrosine ethyl ester
L-Tyrosine, 3-hydroxy-, ethyl ester
3,4-Dihydroxy-L-phenylalanine ethyl ester
ethyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate
2(S)-Amino-3-(3,4-dihydroxyphenyl)propionic acid ethyl ester | [Molecular Formula]
C11H15NO4 | [MDL Number]
MFCD00871210 | [MOL File]
37178-37-3.mol | [Molecular Weight]
225.24 |
| Chemical Properties | Back Directory | [Boiling point ]
394.2±37.0 °C(Predicted) | [density ]
1.278±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
H2O: ≥12mg/mL at warmed to 60°C | [form ]
powder | [pka]
9.67±0.20(Predicted) | [color ]
white to tan | [optical activity]
[α]/D +15 to +19°, c =1 in methanol ([α]/D) | [Water Solubility ]
H2O: ≥12mg/mL atwarmed to 60°C |
| Hazard Information | Back Directory | [Uses]
Antiparkisonian. | [Definition]
ChEBI: Etilevodopa is a tyrosine derivative. | [Biochem/physiol Actions]
L-Dopa ethyl ester is a prodrug of levodopa that has greater gastric solubility. The drug is rapidly hydrolyzed to levodopa by nonspecific esterases in the gastrointestinal tract. L-Dopa ethyl ester (etilevodopa)-carbidopa treatment was well tolerated but did not demonstrate better efficacy compared with standard levodopa-carbidopa treatment. L-Dopa ethyl ester should have a significant brain penetration following an administration by injection. |
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